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dc.contributor.authorWelman, Arkadiusz
dc.contributor.authorSproul, Duncan
dc.contributor.authorMullen, Peter
dc.contributor.authorMuir, Morwenna
dc.contributor.authorKinnaird, Andrew R.
dc.contributor.authorHarrison, David J.
dc.contributor.authorFaratian, Dana
dc.contributor.authorBrunton, Valerie G.
dc.contributor.authorFrame, Margaret C.
dc.date.accessioned2013-11-04T12:31:08Z
dc.date.available2013-11-04T12:31:08Z
dc.date.issued2012-04-13
dc.identifier.citationWelman , A , Sproul , D , Mullen , P , Muir , M , Kinnaird , A R , Harrison , D J , Faratian , D , Brunton , V G & Frame , M C 2012 , ' Diversity of matriptase expression level and function in breast cancer ' , PLoS One , vol. 7 , no. 4 , e34182 . https://doi.org/10.1371/journal.pone.0034182en
dc.identifier.issn1932-6203
dc.identifier.otherPURE: 25744276
dc.identifier.otherPURE UUID: ae1cbf1b-0cac-4918-9d36-62d4a8c7e99b
dc.identifier.otherWOS: 000305341600028
dc.identifier.otherScopus: 84859701243
dc.identifier.otherORCID: /0000-0001-9041-9988/work/64034218
dc.identifier.urihttp://hdl.handle.net/10023/4149
dc.descriptionThis work was funded by Cancer Research UK Program Grant (C157/A9148).en
dc.description.abstractOverexpression of matriptase has been reported in a variety of human cancers and is sufficient to trigger tumor formation in mice, but the importance of matriptase in breast cancer remains unclear. We analysed matriptase expression in 16 human breast cancer cell lines and in 107 primary breast tumors. The data revealed considerable diversity in the expression level of this protein indicating that the significance of matriptase may vary from case to case. Matriptase protein expression was correlated with HER2 expression and highest expression was seen in HER2-positive cell lines, indicating a potential role in this subgroup. Stable overexpression of matriptase in two breast cancer cell lines had different consequences. In MDA-MB-231 human breast carcinoma cells the only noted consequence of matriptase overexpression was modestly impaired growth in vivo. In contrast, overexpression of matriptase in 4T1 mouse breast carcinoma cells resulted in visible changes in morphology, actin staining and cell to cell contacts. This correlated with downregulation of the cell-cell adhesion molecule E-cadherin. These results suggest that the functions of matriptase in breast cancer are likely to be variable and cell context dependent.
dc.format.extent11
dc.language.isoeng
dc.relation.ispartofPLoS Oneen
dc.rights© 2012 Welman et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en
dc.subjectMatriptaseen
dc.subjectBreast canceren
dc.subjectHER2 expressionen
dc.subjectOverexpressionen
dc.subjectE-cadherinen
dc.subjectR Medicineen
dc.subject.lccRen
dc.titleDiversity of matriptase expression level and function in breast canceren
dc.typeJournal articleen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews.School of Medicineen
dc.identifier.doihttps://doi.org/10.1371/journal.pone.0034182
dc.description.statusPeer revieweden


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