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dc.contributor.authorWelman, Arkadiusz
dc.contributor.authorSproul, Duncan
dc.contributor.authorMullen, Peter
dc.contributor.authorMuir, Morwenna
dc.contributor.authorKinnaird, Andrew R.
dc.contributor.authorHarrison, David J.
dc.contributor.authorFaratian, Dana
dc.contributor.authorBrunton, Valerie G.
dc.contributor.authorFrame, Margaret C.
dc.identifier.citationWelman , A , Sproul , D , Mullen , P , Muir , M , Kinnaird , A R , Harrison , D J , Faratian , D , Brunton , V G & Frame , M C 2012 , ' Diversity of matriptase expression level and function in breast cancer ' , PLoS One , vol. 7 , no. 4 , e34182 .
dc.identifier.otherORCID: /0000-0001-9041-9988/work/64034218
dc.identifier.otherORCID: /0000-0002-0841-609X/work/157141011
dc.descriptionThis work was funded by Cancer Research UK Program Grant (C157/A9148).en
dc.description.abstractOverexpression of matriptase has been reported in a variety of human cancers and is sufficient to trigger tumor formation in mice, but the importance of matriptase in breast cancer remains unclear. We analysed matriptase expression in 16 human breast cancer cell lines and in 107 primary breast tumors. The data revealed considerable diversity in the expression level of this protein indicating that the significance of matriptase may vary from case to case. Matriptase protein expression was correlated with HER2 expression and highest expression was seen in HER2-positive cell lines, indicating a potential role in this subgroup. Stable overexpression of matriptase in two breast cancer cell lines had different consequences. In MDA-MB-231 human breast carcinoma cells the only noted consequence of matriptase overexpression was modestly impaired growth in vivo. In contrast, overexpression of matriptase in 4T1 mouse breast carcinoma cells resulted in visible changes in morphology, actin staining and cell to cell contacts. This correlated with downregulation of the cell-cell adhesion molecule E-cadherin. These results suggest that the functions of matriptase in breast cancer are likely to be variable and cell context dependent.
dc.relation.ispartofPLoS Oneen
dc.subjectBreast canceren
dc.subjectHER2 expressionen
dc.subjectR Medicineen
dc.subjectSDG 3 - Good Health and Well-beingen
dc.titleDiversity of matriptase expression level and function in breast canceren
dc.typeJournal articleen
dc.contributor.institutionUniversity of St Andrews. School of Medicineen
dc.description.statusPeer revieweden

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