Now showing items 1-6 of 6

    • Diversity of matriptase expression level and function in breast cancer 

      Welman, Arkadiusz; Sproul, Duncan; Mullen, Peter; Muir, Morwenna; Kinnaird, Andrew R.; Harrison, David J.; Faratian, Dana; Brunton, Valerie G.; Frame, Margaret C. (2012-04-13) - Journal article
      Overexpression of matriptase has been reported in a variety of human cancers and is sufficient to trigger tumor formation in mice, but the importance of matriptase in breast cancer remains unclear. We analysed matriptase ...
    • Lactate, a product of glycolytic metabolism, inhibits histone deacetylase activity and promotes changes in gene expression 

      Latham, Tom; Mackay, Logan; Sproul, Duncan; Karim, Muhammed; Culley, Jayne; Harrison, David J.; Hayward, Larry; Langridge-Smith, Pat; Gilbert, Nick; Ramsahoye, Bernard H. (2012-06) - Journal article
      Chemical inhibitors of histone deacetylase (HDAC) activity are used as experimental tools to induce histone hyperacetylation and deregulate gene transcription, but it is not known whether the inhibition of HDACs plays any ...
    • Targeting of Rac GTPases blocks the spread of intact human breast cancer 

      Katz, Elad; Sims, Andrew H; Sproul, Duncan; Caldwell, Helen; Dixon, Mike; Meehan, Richard R; Harrison, David J (2012-06) - Journal article
      High expression of Rac small GTPases in invasive breast ductal carcinoma is associated with poor prognosis, but its therapeutic value in human cancers is not clear. The aim of the current study was to determine the response ...
    • Tissue of origin determines cancer-associated CpG island promoter hypermethylation patterns 

      Sproul, Duncan; Kitchen, Robert R; Nestor, Colm E; Dixon, J Michael; Sims, Andrew H; Harrison, David J; Ramsahoye, Bernard H; Meehan, Richard R (2012-10-03) - Journal article
      ABSTRACT: BACKGROUND: Aberrant CpG island promoter DNA hypermethylation is frequently observed in cancer and is believed to contribute to tumor progression by silencing the expression of tumor suppressor genes. Previously, ...
    • Tissue type is a major modifier of the 5-hydroxymethylcytosine content of human genes 

      Nestor, Colm E.; Ottaviano, Raffaele; Reddington, James; Sproul, Duncan; Reinhardt, Diana; Dunican, Donncha; Katz, Elad; Dixon, J. Michael; Harrison, David James; Meehan, Richard R. (2012-03) - Journal article
      The discovery of substantial amounts of 5-hydroxymethylcytosine (5hmC), formed by the oxidation of 5-methylcytosine (5mC), in various mouse tissues and human embryonic stem (ES) cells has necessitated a reevaluation of our ...
    • Transcriptionally repressed genes become aberrantly methylated and distinguish tumors of different lineages in breast cancer 

      Sproul, Duncan; Nestor, Colm; Culley, Jayne; Dickson, Jacqueline H.; Dixon, J. Michael; Harrison, David James; Meehan, Richard R.; Sims, Andrew H.; Ramsahoye, Bernard H. (2011-03-15) - Journal article
      Aberrant promoter hypermethylation is frequently observed in cancer. The potential for this mechanism to contribute to tumor development depends on whether the genes affected are repressed because of their methylation. ...