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Lateral entorhinal cortex is necessary for associative but not nonassociative recognition memory

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Wilson_2013_HipCam_Lateral.pdf (555.0Kb)
Date
12/2013
Author
Wilson, David Ian Greig
Watanabe, Sakurako
Milner, Helen Louise
Ainge, James Alexander
Funder
BBSRC
Grant ID
BB/I019367/1
Keywords
Episodic
Hippocampus
Association
Context
Memory
BF Psychology
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Abstract
The lateral entorhinal cortex (LEC) provides one of the two major input pathways to the hippocampus and has been suggested to process the nonspatial contextual details of episodic memory. Combined with spatial information from the medial entorhinal cortex it is hypothesised that this contextual information is used to form an integrated spatially selective, context-specific response in the hippocampus that underlies episodic memory. Recently, we reported that the LEC is required for recognition of objects that have been experienced in a specific context (Wilson et al. (2013) Hippocampus 23:352-366). Here, we sought to extend this work to assess the role of the LEC in recognition of all associative combinations of objects, places and contexts within an episode. Unlike controls, rats with excitotoxic lesions of the LEC showed no evidence of recognizing familiar combinations of object in place, place in context, or object in place and context. However, LEC lesioned rats showed normal recognition of objects and places independently from each other (nonassociative recognition). Together with our previous findings, these data suggest that the LEC is critical for associative recognition memory and may bind together information relating to objects, places, and contexts needed for episodic memory formation.
Citation
Wilson , D I G , Watanabe , S , Milner , H L & Ainge , J A 2013 , ' Lateral entorhinal cortex is necessary for associative but not nonassociative recognition memory ' , Hippocampus . https://doi.org/10.1002/hipo.22165
Publication
Hippocampus
Status
Peer reviewed
DOI
https://doi.org/10.1002/hipo.22165
ISSN
1050-9631
Type
Journal article
Rights
Copyright © 2013 The Authors. Hippocampus Published by Wiley Periodicals, Inc. This is an open access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Description
This work was supported by BBSRC [Grant number BB/I019367/1]
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  • University of St Andrews Research
URI
http://hdl.handle.net/10023/4047

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