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dc.contributor.authorWilson, David Ian Greig
dc.contributor.authorWatanabe, Sakurako
dc.contributor.authorMilner, Helen Louise
dc.contributor.authorAinge, James Alexander
dc.identifier.citationWilson , D I G , Watanabe , S , Milner , H L & Ainge , J A 2013 , ' Lateral entorhinal cortex is necessary for associative but not nonassociative recognition memory ' , Hippocampus .
dc.identifier.otherPURE: 69217490
dc.identifier.otherPURE UUID: e30df498-c224-4811-a2bc-ff55955b268c
dc.identifier.otherScopus: 84888128632
dc.identifier.otherORCID: /0000-0002-0007-1533/work/60428122
dc.descriptionThis work was supported by BBSRC [Grant number BB/I019367/1]en
dc.description.abstractThe lateral entorhinal cortex (LEC) provides one of the two major input pathways to the hippocampus and has been suggested to process the nonspatial contextual details of episodic memory. Combined with spatial information from the medial entorhinal cortex it is hypothesised that this contextual information is used to form an integrated spatially selective, context-specific response in the hippocampus that underlies episodic memory. Recently, we reported that the LEC is required for recognition of objects that have been experienced in a specific context (Wilson et al. (2013) Hippocampus 23:352-366). Here, we sought to extend this work to assess the role of the LEC in recognition of all associative combinations of objects, places and contexts within an episode. Unlike controls, rats with excitotoxic lesions of the LEC showed no evidence of recognizing familiar combinations of object in place, place in context, or object in place and context. However, LEC lesioned rats showed normal recognition of objects and places independently from each other (nonassociative recognition). Together with our previous findings, these data suggest that the LEC is critical for associative recognition memory and may bind together information relating to objects, places, and contexts needed for episodic memory formation.
dc.rightsCopyright © 2013 The Authors. Hippocampus Published by Wiley Periodicals, Inc. This is an open access article under the terms of the Creative Commons Attribution License (, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.en
dc.subjectBF Psychologyen
dc.titleLateral entorhinal cortex is necessary for associative but not nonassociative recognition memoryen
dc.typeJournal articleen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews. School of Psychology and Neuroscienceen
dc.contributor.institutionUniversity of St Andrews. Institute of Behavioural and Neural Sciencesen
dc.description.statusPeer revieweden

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