Now showing items 1-11 of 11

    • Cognitive and neural processes underlying memory for time and context 

      Persson, Bjorn Martin (University of St Andrews, 2017-06-20) - Thesis
      The aim of this thesis is to examine the underlying cognitive and neural processes at play during retrieval of temporal and contextual source information. This was assessed across three experimental chapters. In the first ...
    • Disambiguating past events: accurate source memory for time and context depends on different retrieval processes 

      Persson, Bjorn Martin; Ainge, James Alexander; O'Connor, Akira Robert (2016-07) - Journal article
      Current animal models of episodic memory are usually based on demonstrating integrated memory for what happened, where it happened, and when an event took place. These models aim to capture the testable features of the ...
    • Empirical and methodological investigations into novelty and familiarity as separate processes that support recognition memory in rats and humans 

      Sivakumaran, Magali H. (University of St Andrews, 2018-06-29) - Thesis
      There is a prevalent assumption in the recognition memory literature that the terms “novelty” and “familiarity” are words ascribed to differing extremities of a single memory strength continuum. The aim of the current ...
    • Lateral entorhinal cortex is critical for novel object-context recognition 

      Wilson, David Ian Greig; Langston, Rosamund F.; Schlesiger, Magdalene I.; Wagner, Monica; Watanabe, Sakurako; Ainge, James Alexander (2013-02) - Journal article
      Episodic memory incorporates information about specific events or occasions including spatial locations and the contextual features of the environment in which the event took place. It has been modeled in rats using ...
    • Lateral entorhinal cortex is necessary for associative but not nonassociative recognition memory 

      Wilson, David Ian Greig; Watanabe, Sakurako; Milner, Helen Louise; Ainge, James Alexander (2013-12) - Journal article
      The lateral entorhinal cortex (LEC) provides one of the two major input pathways to the hippocampus and has been suggested to process the nonspatial contextual details of episodic memory. Combined with spatial information ...
    • Lateral entorhinal cortex lesions impair local spatial frameworks 

      Kuruvilla, Maneesh; Ainge, James Alexander (2017-05-17) - Journal article
      A prominent theory in the neurobiology of memory processing is that episodic memory is supported by contextually gated spatial representations in the hippocampus formed by combining spatial information from medial entorhinal ...
    • Mitochondrial β-amyloid in Alzheimer's disease 

      Borger, Eva; Aitken, Laura; Muirhead, Kirsty Elizabeth Adair; Allen, Zoe Eleanor; Ainge, James Alexander; Conway, Stuart; Gunn-Moore, Frank J (2011-08) - Journal article
      It is well established that the intracellular accumulation of beta-amyloid is associated with Alzheimer’s disease and that this accumulation is toxic to neurons. The precise mechanism by which this toxicity occurs is not ...
    • Ontogeny of neural circuits underlying spatial memory in the rat 

      Ainge, James Alexander; Langston, Rosamund F. (2012-03-01) - Journal article
      Spatial memory is a well-characterized psychological function in both humans and rodents. The combined computations of a network of systems including place cells in the hippocampus, grid cells in the medial entorhinal ...
    • Overexpression of endophilin A1 exacerbates synaptic alterations in a mouse model of Alzheimer’s disease 

      Yu, Qing; Wang, Yongfu; Yan, Shijun; Origlia, Nicola; Rutigliano, Grazia; Yu, Haiyang; Ainge, James Alexander; Yan, Shi Fang; Gunn-Moore, Francis James; Yan, Shirley ShiDu (2018-07-30) - Journal article
      Endophilin A1 (EP) is a protein enriched in synaptic terminals that has been linked to Alzheimer’s disease (AD). Previous in vitro studies have shown that EP can bind to a variety of proteins, which elicit changes in ...
    • The role of entorhinal cortex in processing environmental features 

      Kuruvilla, Maneesh (University of St Andrews, 2018) - Thesis
      The medial and lateral entorhinal cortices (MEC; LEC) are widely considered to provide spatial and non-spatial information respectively in the medial temporal lobe, particularly to the hippocampus. However, there is ...
    • Title redacted 

      Dickerson, Katherine Leah (University of St Andrews, 2017-05-31) - Thesis