Three step synthesis of single diastereoisomers of the vicinal trifluoro motif
Abstract
A three step route to single diastereoisomers of the vicinal trifluoromethyl motif is described. The route starts from either syn- or anti-alpha,beta-epoxy alcohols and takes a direct approach in that each of the three steps introduces a fluorine atom in a regio- and stereospecific manner. Starting from either the syn- or the anti-alpha,beta-epoxy alcohol, stereospecific reactions generate two separate diastereoisomeric series of this motif. The route is a significant improvement on an earlier six step strategy.
Citation
Brunet , V A , Slawin , A M Z & O'Hagan , D 2009 , ' Three step synthesis of single diastereoisomers of the vicinal trifluoro motif ' , Beilstein Journal of Organic Chemistry , vol. 5 , 61 . https://doi.org/10.3762/bjoc.5.61
Publication
Beilstein Journal of Organic Chemistry
Status
Peer reviewed
ISSN
1860-5397Type
Journal article
Collections
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