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dc.contributor.authorBrunet, Vincent A.
dc.contributor.authorSlawin, Alexandra M. Z.
dc.contributor.authorO'Hagan, David
dc.date.accessioned2013-03-27T17:01:01Z
dc.date.available2013-03-27T17:01:01Z
dc.date.issued2009-11-05
dc.identifier.citationBrunet , V A , Slawin , A M Z & O'Hagan , D 2009 , ' Three step synthesis of single diastereoisomers of the vicinal trifluoro motif ' , Beilstein Journal of Organic Chemistry , vol. 5 , 61 . https://doi.org/10.3762/bjoc.5.61en
dc.identifier.issn1860-5397
dc.identifier.otherPURE: 16813278
dc.identifier.otherPURE UUID: 05433085-6197-48c5-a6f1-2714d5b466e0
dc.identifier.otherWOS: 000272749900001
dc.identifier.otherScopus: 75949102921
dc.identifier.otherORCID: /0000-0002-9527-6418/work/56861357
dc.identifier.otherORCID: /0000-0002-0510-5552/work/68281205
dc.identifier.urihttps://hdl.handle.net/10023/3443
dc.description.abstractA three step route to single diastereoisomers of the vicinal trifluoromethyl motif is described. The route starts from either syn- or anti-alpha,beta-epoxy alcohols and takes a direct approach in that each of the three steps introduces a fluorine atom in a regio- and stereospecific manner. Starting from either the syn- or the anti-alpha,beta-epoxy alcohol, stereospecific reactions generate two separate diastereoisomeric series of this motif. The route is a significant improvement on an earlier six step strategy.
dc.format.extent9
dc.language.isoeng
dc.relation.ispartofBeilstein Journal of Organic Chemistryen
dc.rights© 2009 Brunet et al; licensee Beilstein-Institut. This is an Open Access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (http://www.beilstein-journals.org/bjoc)en
dc.subjectC-F bonden
dc.subjectorgano-fluorine chemistryen
dc.subjectstereospecific fluorinationen
dc.subjectvicinal trifluoro motifen
dc.subjectKinetic resolutionen
dc.subjectHydrogen-fluorideen
dc.subjectFluorinationen
dc.subjectChemistryen
dc.subjectEpoxidesen
dc.subjectBonden
dc.subjectQD Chemistryen
dc.subject.lccQDen
dc.titleThree step synthesis of single diastereoisomers of the vicinal trifluoro motifen
dc.typeJournal articleen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews. School of Chemistryen
dc.contributor.institutionUniversity of St Andrews. Biomedical Sciences Research Complexen
dc.contributor.institutionUniversity of St Andrews. EaSTCHEMen
dc.identifier.doihttps://doi.org/10.3762/bjoc.5.61
dc.description.statusPeer revieweden


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