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Three step synthesis of single diastereoisomers of the vicinal trifluoro motif
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dc.contributor.author | Brunet, Vincent A. | |
dc.contributor.author | Slawin, Alexandra M. Z. | |
dc.contributor.author | O'Hagan, David | |
dc.date.accessioned | 2013-03-27T17:01:01Z | |
dc.date.available | 2013-03-27T17:01:01Z | |
dc.date.issued | 2009-11-05 | |
dc.identifier | 16813278 | |
dc.identifier | 05433085-6197-48c5-a6f1-2714d5b466e0 | |
dc.identifier | 000272749900001 | |
dc.identifier | 75949102921 | |
dc.identifier.citation | Brunet , V A , Slawin , A M Z & O'Hagan , D 2009 , ' Three step synthesis of single diastereoisomers of the vicinal trifluoro motif ' , Beilstein Journal of Organic Chemistry , vol. 5 , 61 . https://doi.org/10.3762/bjoc.5.61 | en |
dc.identifier.issn | 1860-5397 | |
dc.identifier.other | ORCID: /0000-0002-9527-6418/work/56861357 | |
dc.identifier.other | ORCID: /0000-0002-0510-5552/work/68281205 | |
dc.identifier.uri | https://hdl.handle.net/10023/3443 | |
dc.description.abstract | A three step route to single diastereoisomers of the vicinal trifluoromethyl motif is described. The route starts from either syn- or anti-alpha,beta-epoxy alcohols and takes a direct approach in that each of the three steps introduces a fluorine atom in a regio- and stereospecific manner. Starting from either the syn- or the anti-alpha,beta-epoxy alcohol, stereospecific reactions generate two separate diastereoisomeric series of this motif. The route is a significant improvement on an earlier six step strategy. | |
dc.format.extent | 9 | |
dc.format.extent | 982253 | |
dc.language.iso | eng | |
dc.relation.ispartof | Beilstein Journal of Organic Chemistry | en |
dc.subject | C-F bond | en |
dc.subject | organo-fluorine chemistry | en |
dc.subject | stereospecific fluorination | en |
dc.subject | vicinal trifluoro motif | en |
dc.subject | Kinetic resolution | en |
dc.subject | Hydrogen-fluoride | en |
dc.subject | Fluorination | en |
dc.subject | Chemistry | en |
dc.subject | Epoxides | en |
dc.subject | Bond | en |
dc.subject | QD Chemistry | en |
dc.subject.lcc | QD | en |
dc.title | Three step synthesis of single diastereoisomers of the vicinal trifluoro motif | en |
dc.type | Journal article | en |
dc.contributor.institution | University of St Andrews. School of Chemistry | en |
dc.contributor.institution | University of St Andrews. Biomedical Sciences Research Complex | en |
dc.contributor.institution | University of St Andrews. EaSTCHEM | en |
dc.identifier.doi | 10.3762/bjoc.5.61 | |
dc.description.status | Peer reviewed | en |
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