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Three step synthesis of single diastereoisomers of the vicinal trifluoro motif
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dc.contributor.author | Brunet, Vincent A. | |
dc.contributor.author | Slawin, Alexandra M. Z. | |
dc.contributor.author | O'Hagan, David | |
dc.date.accessioned | 2013-03-27T17:01:01Z | |
dc.date.available | 2013-03-27T17:01:01Z | |
dc.date.issued | 2009-11-05 | |
dc.identifier.citation | Brunet , V A , Slawin , A M Z & O'Hagan , D 2009 , ' Three step synthesis of single diastereoisomers of the vicinal trifluoro motif ' , Beilstein Journal of Organic Chemistry , vol. 5 , 61 . https://doi.org/10.3762/bjoc.5.61 | en |
dc.identifier.issn | 1860-5397 | |
dc.identifier.other | PURE: 16813278 | |
dc.identifier.other | PURE UUID: 05433085-6197-48c5-a6f1-2714d5b466e0 | |
dc.identifier.other | WOS: 000272749900001 | |
dc.identifier.other | Scopus: 75949102921 | |
dc.identifier.other | ORCID: /0000-0002-9527-6418/work/56861357 | |
dc.identifier.other | ORCID: /0000-0002-0510-5552/work/68281205 | |
dc.identifier.uri | https://hdl.handle.net/10023/3443 | |
dc.description.abstract | A three step route to single diastereoisomers of the vicinal trifluoromethyl motif is described. The route starts from either syn- or anti-alpha,beta-epoxy alcohols and takes a direct approach in that each of the three steps introduces a fluorine atom in a regio- and stereospecific manner. Starting from either the syn- or the anti-alpha,beta-epoxy alcohol, stereospecific reactions generate two separate diastereoisomeric series of this motif. The route is a significant improvement on an earlier six step strategy. | |
dc.format.extent | 9 | |
dc.language.iso | eng | |
dc.relation.ispartof | Beilstein Journal of Organic Chemistry | en |
dc.rights | © 2009 Brunet et al; licensee Beilstein-Institut. This is an Open Access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (http://www.beilstein-journals.org/bjoc) | en |
dc.subject | C-F bond | en |
dc.subject | organo-fluorine chemistry | en |
dc.subject | stereospecific fluorination | en |
dc.subject | vicinal trifluoro motif | en |
dc.subject | Kinetic resolution | en |
dc.subject | Hydrogen-fluoride | en |
dc.subject | Fluorination | en |
dc.subject | Chemistry | en |
dc.subject | Epoxides | en |
dc.subject | Bond | en |
dc.subject | QD Chemistry | en |
dc.subject.lcc | QD | en |
dc.title | Three step synthesis of single diastereoisomers of the vicinal trifluoro motif | en |
dc.type | Journal article | en |
dc.description.version | Publisher PDF | en |
dc.contributor.institution | University of St Andrews. School of Chemistry | en |
dc.contributor.institution | University of St Andrews. Biomedical Sciences Research Complex | en |
dc.contributor.institution | University of St Andrews. EaSTCHEM | en |
dc.identifier.doi | https://doi.org/10.3762/bjoc.5.61 | |
dc.description.status | Peer reviewed | en |
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