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ALDH2 mediates 5-nitrofuran activity in multiple species
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dc.contributor.author | Zhou, Linna | |
dc.contributor.author | Ishizaki, Hironori | |
dc.contributor.author | Spitzer, Michaela | |
dc.contributor.author | Taylor, Kerrie | |
dc.contributor.author | Temperley, Nicholas | |
dc.contributor.author | Johnson, Stephen | |
dc.contributor.author | Brear, Paul | |
dc.contributor.author | Gautier, Philippe | |
dc.contributor.author | Zeng, Zhiqiang | |
dc.contributor.author | Mitchell, Amy | |
dc.contributor.author | Narayan, Vikram | |
dc.contributor.author | McNeil, Ewan | |
dc.contributor.author | Melton, David | |
dc.contributor.author | Smith, Terry K | |
dc.contributor.author | Tyers, Mike | |
dc.contributor.author | Westwood, Nicholas James | |
dc.contributor.author | Patton, Elizabeth | |
dc.date.accessioned | 2012-08-14T14:31:01Z | |
dc.date.available | 2012-08-14T14:31:01Z | |
dc.date.issued | 2012-07-27 | |
dc.identifier.citation | Zhou , L , Ishizaki , H , Spitzer , M , Taylor , K , Temperley , N , Johnson , S , Brear , P , Gautier , P , Zeng , Z , Mitchell , A , Narayan , V , McNeil , E , Melton , D , Smith , T K , Tyers , M , Westwood , N J & Patton , E 2012 , ' ALDH2 mediates 5-nitrofuran activity in multiple species ' , Chemistry and Biology , vol. 19 , no. 7 , pp. 883-892 . https://doi.org/10.1016/j.chembiol.2012.05.017 | en |
dc.identifier.issn | 1074-5521 | |
dc.identifier.other | PURE: 22872483 | |
dc.identifier.other | PURE UUID: dd308072-1db7-46f2-b348-fccdce427740 | |
dc.identifier.other | PubMed: 22840776 | |
dc.identifier.other | WOS: 000307261100014 | |
dc.identifier.other | Scopus: 84864408346 | |
dc.identifier.other | ORCID: /0000-0003-0630-0138/work/56424151 | |
dc.identifier.uri | https://hdl.handle.net/10023/3043 | |
dc.description.abstract | Understanding how drugs work in vivo is critical for drug design and for maximizing the potential of currently available drugs. 5-nitrofurans are a class of pro-drugs widely used to treat bacterial and trypanosome infections, but despite relative specificity 5-nitrofurans often cause serious toxic side-effects in people. Here, we use yeast, zebrafish and human in vitro systems to assess the biological activity of 5-nitrofurans, and identify a conserved interaction between aldehyde dehydrogenase (ALDH) 2 and 5-nitrofurans across these species. In addition, we show that the activity of nifurtimox, a 5-nitrofuran anti-trypanosome pro-drug, is dependent on zebrafish Aldh2 and that nifurtimox is a substrate for human ALDH2. This study reveals a conserved and biologically relevant ALDH2-5-nitrofuran interaction that may have important implications for managing the toxicity of 5nitrofuran treatment. | |
dc.format.extent | 10 | |
dc.language.iso | eng | |
dc.relation.ispartof | Chemistry and Biology | en |
dc.rights | This is an author version of this article. The published version Copyright © 2012 Elsevier Ltd is available at www.sciencedirect.com | en |
dc.subject | QD Chemistry | en |
dc.subject.lcc | QD | en |
dc.title | ALDH2 mediates 5-nitrofuran activity in multiple species | en |
dc.type | Journal article | en |
dc.description.version | Postprint | en |
dc.contributor.institution | University of St Andrews. School of Chemistry | en |
dc.contributor.institution | University of St Andrews. Biomedical Sciences Research Complex | en |
dc.contributor.institution | University of St Andrews. School of Biology | en |
dc.contributor.institution | University of St Andrews. EaSTCHEM | en |
dc.identifier.doi | https://doi.org/10.1016/j.chembiol.2012.05.017 | |
dc.description.status | Peer reviewed | en |
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