The University of St Andrews

Research@StAndrews:FullText >
University of St Andrews Research >
University of St Andrews Research >
University of St Andrews Research >

Please use this identifier to cite or link to this item:
This item has been viewed 7 times in the last year. View Statistics

Files in This Item:

File Description SizeFormat
Zhou_et_al.pdf569.98 kBAdobe PDFView/Open
Title: ALDH2 mediates 5-nitrofuran activity in multiple species
Authors: Zhou, Linna
Ishizaki, Hironori
Spitzer, Michaela
Taylor, Kerrie
Temperley, Nicholas
Johnson, Stephen
Brear, Paul
Gautier, Philippe
Zeng, Zhiqiang
Mitchell, Amy
Narayan, Vikram
McNeil, Ewan
Melton, David
Smith, Terry K
Tyers, Mike
Westwood, Nicholas James
Patton, Elizabeth
Keywords: QD Chemistry
Issue Date: 27-Jul-2012
Citation: Zhou , L , Ishizaki , H , Spitzer , M , Taylor , K , Temperley , N , Johnson , S , Brear , P , Gautier , P , Zeng , Z , Mitchell , A , Narayan , V , McNeil , E , Melton , D , Smith , T K , Tyers , M , Westwood , N J & Patton , E 2012 , ' ALDH2 mediates 5-nitrofuran activity in multiple species ' Chemistry and Biology , vol 19 , no. 7 , pp. 883-892 . , 10.1016/j.chembiol.2012.05.017
Abstract: Understanding how drugs work in vivo is critical for drug design and for maximizing the potential of currently available drugs. 5-nitrofurans are a class of pro-drugs widely used to treat bacterial and trypanosome infections, but despite relative specificity 5-nitrofurans often cause serious toxic side-effects in people. Here, we use yeast, zebrafish and human in vitro systems to assess the biological activity of 5-nitrofurans, and identify a conserved interaction between aldehyde dehydrogenase (ALDH) 2 and 5-nitrofurans across these species. In addition, we show that the activity of nifurtimox, a 5-nitrofuran anti-trypanosome pro-drug, is dependent on zebrafish Aldh2 and that nifurtimox is a substrate for human ALDH2. This study reveals a conserved and biologically relevant ALDH2-5-nitrofuran interaction that may have important implications for managing the toxicity of 5nitrofuran treatment.
Version: Postprint
Status: Peer reviewed
ISSN: 1074-5521
Type: Journal article
Rights: This is an author version of this article. The published version Copyright © 2012 Elsevier Ltd is available at
Appears in Collections:University of St Andrews Research
Biology Research
Chemistry Research
Biomedical Sciences Research Complex (BSRC) Research

This item is protected by original copyright

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.


DSpace Software Copyright © 2002-2012  Duraspace - Feedback
For help contact: | Copyright for this page belongs to St Andrews University Library | Terms and Conditions (Cookies)