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Hale2008JnlGenVirology89MultifunctionalNS1.pdf534.81 kBAdobe PDFView/Open
Title: The multifunctional NS1 protein of influenza A viruses
Authors: Hale, Benjamin Geoffrey
Randall, Richard Edward
Ortin, J
Jackson, David
Keywords: Double-stranded-rna
Viral messenger-rna
Temperature-sensitive mutants
Translation initiation-factor
Nucleoctyoplasmic transport
Antiviral responses
QR355 Virology
Issue Date: Oct-2008
Citation: Hale , B G , Randall , R E , Ortin , J & Jackson , D 2008 , ' The multifunctional NS1 protein of influenza A viruses ' Journal of General Virology , vol 89 , no. 10 , pp. 2359-2376 . , 10.1099/vir.0.2008/004606-0
Abstract: The non-structural (NS1) protein of influenza A viruses is a non-essential virulence factor that has multiple accessory functions during viral infection. In recent years, the major role ascribed to NS1 has been its inhibition of host immune responses, especially the limitation of both interferon (IFN) production and the antiviral effects of IFN-induced proteins, such as dsRNA-dependent protein kinase R (PKR) and 2'5'-oligoadenylate synthetase (OAS)/RNase L. However, it is clear that NS1 also acts directly to modulate other important aspects of the virus replication cycle, including viral RNA replication, viral protein synthesis, and general host-cell physiology. Here, we review the current literature on this remarkably multifunctional viral protein. In the first part of this article, we summarize the basic biochemistry of NS1, in particular its synthesis, structure, and intracellular localization. We then discuss the various roles NS1 has in regulating viral replication mechanisms, host innate/adaptive immune responses, and cellular signalling pathways. We focus on the NS1-RNA and NS1-protein interactions that are fundamental to these processes, and highlight apparent strain-specific ways in which different NS1 proteins may act. In this regard, the contributions of certain NS1 functions to the pathogenicity of human and animal influenza A viruses are also discussed. Finally, we outline practical applications that future studies on NS1 may lead to, including the rational design and manufacture of influenza vaccines, the development of novel antiviral drugs, and the use of oncolytic influenza A viruses as potential anti-cancer agents.
Version: Publisher PDF
Status: Peer reviewed
ISSN: 0022-1317
Type: Journal article
Rights: (c) 2008 SGM. This is an open access article published in Journal of General Virology
Appears in Collections:University of St Andrews Research
Biology Research
Biomedical Sciences Research Complex (BSRC) Research

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