Now showing items 1-6 of 6

    • Crystal structure of human IPS-1/MAVS/VISA/Cardif caspase activation recruitment domain 

      Potter, Jane A.; Randall, Richard Edward; Taylor, Garry L. (2008-02-28) - Journal article
      Background: IPS-1/MAVS/VISA/Cardif is an adaptor protein that plays a crucial role in the induction of interferons in response to viral infection. In the initial stage of the intracellular antiviral response two RNA ...
    • Deep sequencing analysis of defective genomes of parainfluenza virus 5 and their role in interferon induction 

      Killip, M. J.; Young, D. F.; Gatherer, D.; Ross, C. S.; Short, J. A. L.; Davison, A. J.; Goodbourn, S.; Randall, R. E. (2013-05) - Journal article
      Preparations of parainfluenza virus 5 (PIV5) that are potent activators of the interferon (IFN) induction cascade were generated by high-multiplicity passage in order to accumulate defective interfering virus genomes (DIs). ...
    • Innate sensing of HIV-infected cells 

      Lepelley, Alice; Louis, Stephanie; Sourisseau, Marion; Law, Helen K. W.; Pothlichet, Julien; Schilte, Clementine; Chaperot, Laurence; Plumas, Joel; Randall, Richard Edward; Si-Tahar, Mustapha; Mammano, Fabrizio; Albert, Matthew L.; Schwartz, Olivier (2011-02) - Journal article
      Cell-free HIV-1 virions are poor stimulators of type I interferon (IFN) production. We examined here how HIV-infected cells are recognized by plasmacytoid dendritic cells (pDCs) and by other cells. We show that infected ...
    • LGP2 plays a critical role in sensitizing mda-5 to activation by double-stranded RNA 

      Childs, Kay S.; Randall, Richard E.; Goodbourn, Stephen (2013-05-09) - Journal article
      The DExD/H box RNA helicases retinoic acid-inducible gene-I (RIG-I) and melanoma differentiation associated gene-5 (mda-5) sense viral RNA in the cytoplasm of infected cells and activate signal transduction pathways that ...
    • The multifunctional NS1 protein of influenza A viruses 

      Hale, Benjamin Geoffrey; Randall, Richard Edward; Ortin, J; Jackson, David (2008-10) - Journal article
      The non-structural (NS1) protein of influenza A viruses is a non-essential virulence factor that has multiple accessory functions during viral infection. In recent years, the major role ascribed to NS1 has been its inhibition ...
    • Mumps virus Enders strain is sensitive to interferon (IFN) despite encoding a functional IFN antagonist 

      Young, D F; Galiano, M; Lemon, K; Chen, Y-H; Andrejeva, Jelena; Duprex, P; Rima, B K; Randall, Richard Edward (2009-11) - Journal article
      Although the Enders strain of mumps virus (MuV) encodes a functional V protein that acts as an interferon (IFN) antagonist, in multi-cycle growth assays MuV Enders grew poorly in naive ('IFN-competent' Hep2) cells but grew ...