Family size and duration of fertility in female cancer survivors : a population based analysis
MetadataShow full item record
Altmetrics Handle Statistics
Altmetrics DOI Statistics
Objective: To assess family size and timescale for achieving pregnancy in women who remain fertile after cancer. Design: Population-based analysis. Setting: National databases. Patient(s): All women diagnosed with cancer before the age of 40 years in Scotland, 1981–2012 (n = 10,267) with no previous pregnancy; each was matched with 3 population controls. Intervention(s): None. Main Outcome Measure(s): The number and timing of pregnancy and live birth after cancer diagnosis, to 2018. Result(s): In 10,267 cancer survivors, the hazard ratio for a subsequent live birth was 0.56 (95% confidence interval, 0.53–0.58) overall. In women who achieved a subsequent pregnancy, age at live birth increased (mean ± SD, 31.2 ± 5.5 vs. 29.7 ± 6.1 in controls), and the family size was lower (2.0 ± 0.8 vs. 2.3 ± 1.1 live births). These findings were consistent across several diagnoses. The interval from diagnosis to last pregnancy was similar to that of controls (10.7 ± 6.4 vs. 10.9 ± 7.3 years) or significantly increased, for example, after breast cancer (6.2 ± 2.8 vs. 5.3 ± 3.3 years) and Hodgkin lymphoma (11.1 ± 5.1 vs. 10.1 ± 5.8 years). Conclusion(s): These data quantify the reduced chance of live birth after cancer. Women who subsequently conceived achieved a smaller family size than matched controls, but the period of time after cancer diagnosis across which pregnancies occurred was similar or, indeed, increased. Thus, we did not find evidence that women who were able to achieve a pregnancy after cancer had a shorter timescale over which they have pregnancies.
Anderson , R A , Kelsey , T , Morrison , D S & Wallace , W H B 2022 , ' Family size and duration of fertility in female cancer survivors : a population based analysis ' , Fertility and Sterility , vol. 117 , no. 2 , pp. 387-395 . https://doi.org/10.1016/j.fertnstert.2021.11.011
Fertility and Sterility
Copyright © 2021 The Authors. Published by Elsevier Inc. on behalf of the American Society for Reproductive Medicine. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
DescriptionFunder: R.A.A. reports grant from Medical Research Council for the submitted work (Grant No. MR/N022556/1). T.W.K. has nothing to disclose. D.S.M. has nothing to disclose. W.H.B.W. has nothing to disclose.
Items in the St Andrews Research Repository are protected by copyright, with all rights reserved, unless otherwise indicated.