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dc.contributor.authorAnderson, Richard A.
dc.contributor.authorKelsey, Tom
dc.contributor.authorMorrison, David S.
dc.contributor.authorWallace, W. Hamish B.
dc.identifier.citationAnderson , R A , Kelsey , T , Morrison , D S & Wallace , W H B 2022 , ' Family size and duration of fertility in female cancer survivors : a population based analysis ' , Fertility and Sterility , vol. 117 , no. 2 , pp. 387-395 .
dc.identifier.otherPURE: 275787467
dc.identifier.otherPURE UUID: 8f93030f-fe74-4c13-8794-2b196e4f441f
dc.identifier.otherORCID: /0000-0002-8091-1458/work/105006926
dc.identifier.otherScopus: 85121371420
dc.identifier.otherWOS: 000765385300024
dc.descriptionFunder: R.A.A. reports grant from Medical Research Council for the submitted work (Grant No. MR/N022556/1). T.W.K. has nothing to disclose. D.S.M. has nothing to disclose. W.H.B.W. has nothing to disclose.en
dc.description.abstractObjective: To assess family size and timescale for achieving pregnancy in women who remain fertile after cancer. Design: Population-based analysis. Setting: National databases. Patient(s): All women diagnosed with cancer before the age of 40 years in Scotland, 1981–2012 (n = 10,267) with no previous pregnancy; each was matched with 3 population controls. Intervention(s): None. Main Outcome Measure(s): The number and timing of pregnancy and live birth after cancer diagnosis, to 2018. Result(s): In 10,267 cancer survivors, the hazard ratio for a subsequent live birth was 0.56 (95% confidence interval, 0.53–0.58) overall. In women who achieved a subsequent pregnancy, age at live birth increased (mean ± SD, 31.2 ± 5.5 vs. 29.7 ± 6.1 in controls), and the family size was lower (2.0 ± 0.8 vs. 2.3 ± 1.1 live births). These findings were consistent across several diagnoses. The interval from diagnosis to last pregnancy was similar to that of controls (10.7 ± 6.4 vs. 10.9 ± 7.3 years) or significantly increased, for example, after breast cancer (6.2 ± 2.8 vs. 5.3 ± 3.3 years) and Hodgkin lymphoma (11.1 ± 5.1 vs. 10.1 ± 5.8 years). Conclusion(s): These data quantify the reduced chance of live birth after cancer. Women who subsequently conceived achieved a smaller family size than matched controls, but the period of time after cancer diagnosis across which pregnancies occurred was similar or, indeed, increased. Thus, we did not find evidence that women who were able to achieve a pregnancy after cancer had a shorter timescale over which they have pregnancies.
dc.relation.ispartofFertility and Sterilityen
dc.rightsCopyright © 2021 The Authors. Published by Elsevier Inc. on behalf of the American Society for Reproductive Medicine. This is an open access article under the CC BY-NC-ND license (
dc.subjectReproductive lifespanen
dc.subjectQA75 Electronic computers. Computer scienceen
dc.subjectRC0254 Neoplasms. Tumors. Oncology (including Cancer)en
dc.subjectRG Gynecology and obstetricsen
dc.titleFamily size and duration of fertility in female cancer survivors : a population based analysisen
dc.typeJournal articleen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews. School of Computer Scienceen
dc.contributor.institutionUniversity of St Andrews. Sir James Mackenzie Institute for Early Diagnosisen
dc.contributor.institutionUniversity of St Andrews. Centre for Interdisciplinary Research in Computational Algebraen
dc.description.statusPeer revieweden

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