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Friend or enemy? : Review of 17β‐HSD10 and its role in human health or disease

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Gunn_Moore_2020_JofNeur_Friendoreneny_AAM.pdf (22.37Mb)
Date
23/05/2020
Author
Vinklarova, Lucie
Schmidt, Monika
Benek, Ondrej
Kuca, Kamil
Gunn-Moore, Frank
Musilek, Kamil
Keywords
17β-hydroxysteroid dehydrogenase type 10
Alzheimer’s disease
Cancer
Estradiol
HSD10
Neurosteroid
QH301 Biology
RC0254 Neoplasms. Tumors. Oncology (including Cancer)
RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
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Abstract
17β‐hydroxysteroid dehydrogenase (17β‐HSD10) is a multifunctional human enzyme with important roles both as a structural component and also as a catalyst of many metabolic pathways. This mitochondrial enzyme has important functions in the metabolism, development and aging of the neural system, where it is involved in the homeostasis of neurosteroids, especially in regard to estradiol, changes in which make it an essential part of neurodegenerative pathology. These roles therefore, indicate that 17β‐HSD10 may be a possible druggable target for neurodegenerative diseases including Alzheimer’s disease (AD), and in hormone dependent cancer. The objective of this review is to provide a summary about physiological functions and pathological roles of 17β‐HSD10 and the modulators of its activity.
Citation
Vinklarova , L , Schmidt , M , Benek , O , Kuca , K , Gunn-Moore , F & Musilek , K 2020 , ' Friend or enemy? Review of 17β‐HSD10 and its role in human health or disease ' , Journal of Neurochemistry , vol. Early view . https://doi.org/10.1111/jnc.15027
Publication
Journal of Neurochemistry
Status
Peer reviewed
DOI
https://doi.org/10.1111/jnc.15027
ISSN
0022-3042
Type
Journal item
Rights
© 2020 International Society for Neurochemistry. This work has been made available online in accordance with publisher policies or with permission. Permission for further reuse of this content should be sought from the publisher or the rights holder. This is the author created accepted manuscript following peer review and may differ slightly from the final published version. The final published version of this work is available at https://doi.org/10.1111/jnc.15027
Description
Funding: Ministry of Health of the Czech Republic (no. NV19-09-00578), Ministry of Education, Youth and Sports of the Czech Republic (project ESF no. CZ.02.1.01/0.0/0.0/18_069/0010054), University of Hradec Kralove (Faculty of Science, no. VT2019-2021, SV2113-2019, and Postdoctoral job positions at UHK), Wellcome Trust (204821/Z/16/Z), The Rosetrees Trust and the RS MacDonald Charitable Trust.
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  • University of St Andrews Research
URI
http://hdl.handle.net/10023/23234

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