Friend or enemy? : Review of 17β‐HSD10 and its role in human health or disease
Abstract
17β‐hydroxysteroid dehydrogenase (17β‐HSD10) is a multifunctional human enzyme with important roles both as a structural component and also as a catalyst of many metabolic pathways. This mitochondrial enzyme has important functions in the metabolism, development and aging of the neural system, where it is involved in the homeostasis of neurosteroids, especially in regard to estradiol, changes in which make it an essential part of neurodegenerative pathology. These roles therefore, indicate that 17β‐HSD10 may be a possible druggable target for neurodegenerative diseases including Alzheimer’s disease (AD), and in hormone dependent cancer. The objective of this review is to provide a summary about physiological functions and pathological roles of 17β‐HSD10 and the modulators of its activity.
Citation
Vinklarova , L , Schmidt , M , Benek , O , Kuca , K , Gunn-Moore , F & Musilek , K 2020 , ' Friend or enemy? Review of 17β‐HSD10 and its role in human health or disease ' , Journal of Neurochemistry , vol. Early view . https://doi.org/10.1111/jnc.15027
Publication
Journal of Neurochemistry
Status
Peer reviewed
ISSN
0022-3042Type
Journal item
Description
Funding: Ministry of Health of the Czech Republic (no. NV19-09-00578), Ministry of Education, Youth and Sports of the Czech Republic (project ESF no. CZ.02.1.01/0.0/0.0/18_069/0010054), University of Hradec Kralove (Faculty of Science, no. VT2019-2021, SV2113-2019, and Postdoctoral job positions at UHK), Wellcome Trust (204821/Z/16/Z), The Rosetrees Trust and the RS MacDonald Charitable Trust.Collections
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