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Friend or enemy? : Review of 17β‐HSD10 and its role in human health or disease

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dc.contributor.authorVinklarova, Lucie
dc.contributor.authorSchmidt, Monika
dc.contributor.authorBenek, Ondrej
dc.contributor.authorKuca, Kamil
dc.contributor.authorGunn-Moore, Frank
dc.contributor.authorMusilek, Kamil
dc.date.accessioned2021-05-22T23:40:33Z
dc.date.available2021-05-22T23:40:33Z
dc.date.issued2020-05-23
dc.identifier.citationVinklarova , L , Schmidt , M , Benek , O , Kuca , K , Gunn-Moore , F & Musilek , K 2020 , ' Friend or enemy? Review of 17β‐HSD10 and its role in human health or disease ' , Journal of Neurochemistry , vol. Early view . https://doi.org/10.1111/jnc.15027en
dc.identifier.issn0022-3042
dc.identifier.otherPURE: 267545996
dc.identifier.otherPURE UUID: d1b52d5a-4c8b-4d5b-867e-4a8382722d26
dc.identifier.otherRIS: urn:3ED8E1459FD9AD182FAF54CAE807025B
dc.identifier.otherWOS: 000534755100001
dc.identifier.otherScopus: 85085543210
dc.identifier.urihttp://hdl.handle.net/10023/23234
dc.descriptionFunding: Ministry of Health of the Czech Republic (no. NV19-09-00578), Ministry of Education, Youth and Sports of the Czech Republic (project ESF no. CZ.02.1.01/0.0/0.0/18_069/0010054), University of Hradec Kralove (Faculty of Science, no. VT2019-2021, SV2113-2019, and Postdoctoral job positions at UHK), Wellcome Trust (204821/Z/16/Z), The Rosetrees Trust and the RS MacDonald Charitable Trust.en
dc.description.abstract17β‐hydroxysteroid dehydrogenase (17β‐HSD10) is a multifunctional human enzyme with important roles both as a structural component and also as a catalyst of many metabolic pathways. This mitochondrial enzyme has important functions in the metabolism, development and aging of the neural system, where it is involved in the homeostasis of neurosteroids, especially in regard to estradiol, changes in which make it an essential part of neurodegenerative pathology. These roles therefore, indicate that 17β‐HSD10 may be a possible druggable target for neurodegenerative diseases including Alzheimer’s disease (AD), and in hormone dependent cancer. The objective of this review is to provide a summary about physiological functions and pathological roles of 17β‐HSD10 and the modulators of its activity.
dc.language.isoeng
dc.relation.ispartofJournal of Neurochemistryen
dc.rights© 2020 International Society for Neurochemistry. This work has been made available online in accordance with publisher policies or with permission. Permission for further reuse of this content should be sought from the publisher or the rights holder. This is the author created accepted manuscript following peer review and may differ slightly from the final published version. The final published version of this work is available at https://doi.org/10.1111/jnc.15027en
dc.subject17β-hydroxysteroid dehydrogenase type 10en
dc.subjectAlzheimer’s diseaseen
dc.subjectCanceren
dc.subjectEstradiolen
dc.subjectHSD10en
dc.subjectNeurosteroiden
dc.subjectQH301 Biologyen
dc.subjectRC0254 Neoplasms. Tumors. Oncology (including Cancer)en
dc.subjectRC0321 Neuroscience. Biological psychiatry. Neuropsychiatryen
dc.subject.lccQH301en
dc.subject.lccRC0254en
dc.subject.lccRC0321en
dc.titleFriend or enemy? : Review of 17β‐HSD10 and its role in human health or diseaseen
dc.typeJournal itemen
dc.description.versionPostprinten
dc.contributor.institutionUniversity of St Andrews.School of Biologyen
dc.contributor.institutionUniversity of St Andrews.Sir James Mackenzie Institute for Early Diagnosisen
dc.contributor.institutionUniversity of St Andrews.Centre for Biophotonicsen
dc.contributor.institutionUniversity of St Andrews.Institute of Behavioural and Neural Sciencesen
dc.contributor.institutionUniversity of St Andrews.Biomedical Sciences Research Complexen
dc.identifier.doihttps://doi.org/10.1111/jnc.15027
dc.description.statusPeer revieweden
dc.date.embargoedUntil2021-05-23


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