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Friend or enemy? : Review of 17β‐HSD10 and its role in human health or disease
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dc.contributor.author | Vinklarova, Lucie | |
dc.contributor.author | Schmidt, Monika | |
dc.contributor.author | Benek, Ondrej | |
dc.contributor.author | Kuca, Kamil | |
dc.contributor.author | Gunn-Moore, Frank | |
dc.contributor.author | Musilek, Kamil | |
dc.date.accessioned | 2021-05-22T23:40:33Z | |
dc.date.available | 2021-05-22T23:40:33Z | |
dc.date.issued | 2020-05-23 | |
dc.identifier.citation | Vinklarova , L , Schmidt , M , Benek , O , Kuca , K , Gunn-Moore , F & Musilek , K 2020 , ' Friend or enemy? Review of 17β‐HSD10 and its role in human health or disease ' , Journal of Neurochemistry , vol. Early view . https://doi.org/10.1111/jnc.15027 | en |
dc.identifier.issn | 0022-3042 | |
dc.identifier.other | PURE: 267545996 | |
dc.identifier.other | PURE UUID: d1b52d5a-4c8b-4d5b-867e-4a8382722d26 | |
dc.identifier.other | RIS: urn:3ED8E1459FD9AD182FAF54CAE807025B | |
dc.identifier.other | WOS: 000534755100001 | |
dc.identifier.other | Scopus: 85085543210 | |
dc.identifier.uri | http://hdl.handle.net/10023/23234 | |
dc.description | Funding: Ministry of Health of the Czech Republic (no. NV19-09-00578), Ministry of Education, Youth and Sports of the Czech Republic (project ESF no. CZ.02.1.01/0.0/0.0/18_069/0010054), University of Hradec Kralove (Faculty of Science, no. VT2019-2021, SV2113-2019, and Postdoctoral job positions at UHK), Wellcome Trust (204821/Z/16/Z), The Rosetrees Trust and the RS MacDonald Charitable Trust. | en |
dc.description.abstract | 17β‐hydroxysteroid dehydrogenase (17β‐HSD10) is a multifunctional human enzyme with important roles both as a structural component and also as a catalyst of many metabolic pathways. This mitochondrial enzyme has important functions in the metabolism, development and aging of the neural system, where it is involved in the homeostasis of neurosteroids, especially in regard to estradiol, changes in which make it an essential part of neurodegenerative pathology. These roles therefore, indicate that 17β‐HSD10 may be a possible druggable target for neurodegenerative diseases including Alzheimer’s disease (AD), and in hormone dependent cancer. The objective of this review is to provide a summary about physiological functions and pathological roles of 17β‐HSD10 and the modulators of its activity. | |
dc.language.iso | eng | |
dc.relation.ispartof | Journal of Neurochemistry | en |
dc.rights | © 2020 International Society for Neurochemistry. This work has been made available online in accordance with publisher policies or with permission. Permission for further reuse of this content should be sought from the publisher or the rights holder. This is the author created accepted manuscript following peer review and may differ slightly from the final published version. The final published version of this work is available at https://doi.org/10.1111/jnc.15027 | en |
dc.subject | 17β-hydroxysteroid dehydrogenase type 10 | en |
dc.subject | Alzheimer’s disease | en |
dc.subject | Cancer | en |
dc.subject | Estradiol | en |
dc.subject | HSD10 | en |
dc.subject | Neurosteroid | en |
dc.subject | QH301 Biology | en |
dc.subject | RC0254 Neoplasms. Tumors. Oncology (including Cancer) | en |
dc.subject | RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry | en |
dc.subject.lcc | QH301 | en |
dc.subject.lcc | RC0254 | en |
dc.subject.lcc | RC0321 | en |
dc.title | Friend or enemy? : Review of 17β‐HSD10 and its role in human health or disease | en |
dc.type | Journal item | en |
dc.description.version | Postprint | en |
dc.contributor.institution | University of St Andrews.School of Biology | en |
dc.contributor.institution | University of St Andrews.Sir James Mackenzie Institute for Early Diagnosis | en |
dc.contributor.institution | University of St Andrews.Centre for Biophotonics | en |
dc.contributor.institution | University of St Andrews.Institute of Behavioural and Neural Sciences | en |
dc.contributor.institution | University of St Andrews.Biomedical Sciences Research Complex | en |
dc.identifier.doi | https://doi.org/10.1111/jnc.15027 | |
dc.description.status | Peer reviewed | en |
dc.date.embargoedUntil | 2021-05-23 |
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