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Object and object-memory representations across the proximodistal axis of CA1

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Date
20/07/2021
Author
Vandrey, Brianna
Duncan, Stephen
Ainge, James Alexander
Keywords
CA1 region
Entorhinal cortex
Episodic memory
Hippocampus
Place cell
Spatial memory
RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
NDAS
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Abstract
Episodic memory requires information about objects to be integrated into a spatial framework. Place cells in the hippocampus encode spatial representations of objects that could be generated through signaling from the entorhinal cortex. Projections from lateral (LEC) and medial entorhinal cortex (MEC) to the hippocampus terminate in distal and proximal CA1, respectively. We recorded place cells in distal and proximal CA1 as rats explored an environment that contained objects. Place cells in distal CA1 demonstrated higher measures of spatial tuning, stability, and closer proximity of place fields to objects. Furthermore, remapping to object displacement was modulated by place field proximity to objects in distal, but not proximal CA1. Finally, representations of previous object locations were closer to those locations in distal CA1 than proximal CA1. Our data suggest that in cue‐rich environments, LEC inputs to the hippocampus support spatial representations with higher spatial tuning, closer proximity to objects, and greater stability than those receiving inputs from MEC. This is consistent with functional segregation in the entorhinal–hippocampal circuits underlying object‐place memory.
Citation
Vandrey , B , Duncan , S & Ainge , J A 2021 , ' Object and object-memory representations across the proximodistal axis of CA1 ' , Hippocampus , vol. 31 , no. 8 , pp. 881-896 . https://doi.org/10.1002/hipo.23331
Publication
Hippocampus
Status
Peer reviewed
DOI
https://doi.org/10.1002/hipo.23331
ISSN
1050-9631
Type
Journal article
Rights
Copyright © 2021 The Authors. Hippocampus published by Wiley Periodicals LLC. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Description
Funding: Royal Society of Edinburgh (Grant Number(s): Henry Dryerre scholarship).
Collections
  • University of St Andrews Research
URL
https://www.biorxiv.org/content/10.1101/2020.06.19.160911v1
URI
http://hdl.handle.net/10023/23123

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