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dc.contributor.authorVandrey, Brianna
dc.contributor.authorDuncan, Stephen
dc.contributor.authorAinge, James Alexander
dc.date.accessioned2021-05-06T15:30:29Z
dc.date.available2021-05-06T15:30:29Z
dc.date.issued2021-07-20
dc.identifier.citationVandrey , B , Duncan , S & Ainge , J A 2021 , ' Object and object-memory representations across the proximodistal axis of CA1 ' , Hippocampus , vol. 31 , no. 8 , pp. 881-896 . https://doi.org/10.1002/hipo.23331en
dc.identifier.issn1050-9631
dc.identifier.otherPURE: 273716945
dc.identifier.otherPURE UUID: 544654ba-2547-40c0-9d85-4aca421ba1de
dc.identifier.otherORCID: /0000-0002-0007-1533/work/93515206
dc.identifier.otherWOS: 000646466100001
dc.identifier.otherScopus: 85105077687
dc.identifier.urihttp://hdl.handle.net/10023/23123
dc.descriptionFunding: Royal Society of Edinburgh (Grant Number(s): Henry Dryerre scholarship).en
dc.description.abstractEpisodic memory requires information about objects to be integrated into a spatial framework. Place cells in the hippocampus encode spatial representations of objects that could be generated through signaling from the entorhinal cortex. Projections from lateral (LEC) and medial entorhinal cortex (MEC) to the hippocampus terminate in distal and proximal CA1, respectively. We recorded place cells in distal and proximal CA1 as rats explored an environment that contained objects. Place cells in distal CA1 demonstrated higher measures of spatial tuning, stability, and closer proximity of place fields to objects. Furthermore, remapping to object displacement was modulated by place field proximity to objects in distal, but not proximal CA1. Finally, representations of previous object locations were closer to those locations in distal CA1 than proximal CA1. Our data suggest that in cue‐rich environments, LEC inputs to the hippocampus support spatial representations with higher spatial tuning, closer proximity to objects, and greater stability than those receiving inputs from MEC. This is consistent with functional segregation in the entorhinal–hippocampal circuits underlying object‐place memory.
dc.format.extent16
dc.language.isoeng
dc.relation.ispartofHippocampusen
dc.rightsCopyright © 2021 The Authors. Hippocampus published by Wiley Periodicals LLC. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.en
dc.subjectCA1 regionen
dc.subjectEntorhinal cortexen
dc.subjectEpisodic memoryen
dc.subjectHippocampusen
dc.subjectPlace cellen
dc.subjectSpatial memoryen
dc.subjectRC0321 Neuroscience. Biological psychiatry. Neuropsychiatryen
dc.subjectNDASen
dc.subject.lccRC0321en
dc.titleObject and object-memory representations across the proximodistal axis of CA1en
dc.typeJournal articleen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews.School of Psychology and Neuroscienceen
dc.identifier.doihttps://doi.org/10.1002/hipo.23331
dc.description.statusPeer revieweden
dc.identifier.urlhttps://www.biorxiv.org/content/10.1101/2020.06.19.160911v1en


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