Diagnostic accuracy of quantitative micro-elastography for margin assessment in breast-conserving surgery
Abstract
Inadequate margins in breast-conserving surgery (BCS) are associated with an increased likelihood of local recurrence of breast cancer. Currently, approximately 20% of BCS patients require repeat surgery due to inadequate margins at the initial operation. Implementation of an accurate, intraoperative margin assessment tool may reduce this re-excision rate. This study determined, for the first time, the diagnostic accuracy of quantitative micro-elastography (QME), an optical coherence tomography (OCT)-based elastography technique that produces images of tissue microscale elasticity, for detecting tumor within 1 mm of the margins of BCS specimens. Simultaneous OCT and QME were performed on the margins of intact, freshly excised specimens from 83 patients undergoing BCS and on dissected specimens from 7 patients undergoing mastectomy. The resulting three-dimensional images (45 × 45 × 1 mm) were coregistered with postoperative histology to determine tissue types present in each scan. Data from 12 BCS patients and the 7 mastectomy patients served to build a set of images for reader training. One hundred and fifty-four subimages (10 × 10 × 1 mm) from the remaining 71 BCS patients were included in a blinded reader study, which resulted in 69.0% sensitivity and 79.0% specificity using OCT images, versus 92.9% sensitivity and 96.4% specificity using elasticity images. The quantitative nature of QME also facilitated development of an automated reader, which resulted in 100.0% sensitivity and 97.7% specificity. These results demonstrate high accuracy of QME for detecting tumor within 1 mm of the margin and the potential for this technique to improve outcomes in BCS. Significance : An optical imaging technology probes breast tissue elasticity to provide accurate assessment of tumor margin involvement in breast-conserving surgery.
Citation
Kennedy , K M , Zilkens , R , Allen , W M , Foo , K Y , Fang , Q , Chin , L , Sanderson , R W , Anstie , J , Wijesinghe , P , Curatolo , A , Tan , H E I , Morin , N , Kunjuraman , B , Yeomans , C , Chin , S L , DeJong , H , Giles , K , Dessauvagie , B F , Latham , B , Saunders , C M & Kennedy , B F 2020 , ' Diagnostic accuracy of quantitative micro-elastography for margin assessment in breast-conserving surgery ' , Cancer Research , vol. 80 , no. 8 , pp. 1773-1783 . https://doi.org/10.1158/0008-5472.CAN-19-1240
Publication
Cancer Research
Status
Peer reviewed
ISSN
0008-5472Type
Journal article
Description
Funding: OncoRes Medical; Department of Health, Australia; Cancer Council Western Australia; Australian Research Council.Collections
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