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Diagnostic accuracy of quantitative micro-elastography for margin assessment in breast-conserving surgery
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dc.contributor.author | Kennedy, Kelsey M | |
dc.contributor.author | Zilkens, Renate | |
dc.contributor.author | Allen, Wes M | |
dc.contributor.author | Foo, Ken Y | |
dc.contributor.author | Fang, Qi | |
dc.contributor.author | Chin, Lixin | |
dc.contributor.author | Sanderson, Rowan W | |
dc.contributor.author | Anstie, James | |
dc.contributor.author | Wijesinghe, Philip | |
dc.contributor.author | Curatolo, Andrea | |
dc.contributor.author | Tan, Hsern Ern I | |
dc.contributor.author | Morin, Narelle | |
dc.contributor.author | Kunjuraman, Bindu | |
dc.contributor.author | Yeomans, Chris | |
dc.contributor.author | Chin, Synn Lynn | |
dc.contributor.author | DeJong, Helen | |
dc.contributor.author | Giles, Katharine | |
dc.contributor.author | Dessauvagie, Benjamin F | |
dc.contributor.author | Latham, Bruce | |
dc.contributor.author | Saunders, Christobel M | |
dc.contributor.author | Kennedy, Brendan F | |
dc.date.accessioned | 2021-04-14T23:49:58Z | |
dc.date.available | 2021-04-14T23:49:58Z | |
dc.date.issued | 2020-04 | |
dc.identifier | 267606855 | |
dc.identifier | cbf577dc-b009-45e3-a52e-910519d0afdb | |
dc.identifier | 32295783 | |
dc.identifier | 85083481191 | |
dc.identifier | 000526057400014 | |
dc.identifier.citation | Kennedy , K M , Zilkens , R , Allen , W M , Foo , K Y , Fang , Q , Chin , L , Sanderson , R W , Anstie , J , Wijesinghe , P , Curatolo , A , Tan , H E I , Morin , N , Kunjuraman , B , Yeomans , C , Chin , S L , DeJong , H , Giles , K , Dessauvagie , B F , Latham , B , Saunders , C M & Kennedy , B F 2020 , ' Diagnostic accuracy of quantitative micro-elastography for margin assessment in breast-conserving surgery ' , Cancer Research , vol. 80 , no. 8 , pp. 1773-1783 . https://doi.org/10.1158/0008-5472.CAN-19-1240 | en |
dc.identifier.issn | 0008-5472 | |
dc.identifier.other | ORCID: /0000-0002-8378-7261/work/72842839 | |
dc.identifier.uri | https://hdl.handle.net/10023/23031 | |
dc.description | Funding: OncoRes Medical; Department of Health, Australia; Cancer Council Western Australia; Australian Research Council. | en |
dc.description.abstract | Inadequate margins in breast-conserving surgery (BCS) are associated with an increased likelihood of local recurrence of breast cancer. Currently, approximately 20% of BCS patients require repeat surgery due to inadequate margins at the initial operation. Implementation of an accurate, intraoperative margin assessment tool may reduce this re-excision rate. This study determined, for the first time, the diagnostic accuracy of quantitative micro-elastography (QME), an optical coherence tomography (OCT)-based elastography technique that produces images of tissue microscale elasticity, for detecting tumor within 1 mm of the margins of BCS specimens. Simultaneous OCT and QME were performed on the margins of intact, freshly excised specimens from 83 patients undergoing BCS and on dissected specimens from 7 patients undergoing mastectomy. The resulting three-dimensional images (45 × 45 × 1 mm) were coregistered with postoperative histology to determine tissue types present in each scan. Data from 12 BCS patients and the 7 mastectomy patients served to build a set of images for reader training. One hundred and fifty-four subimages (10 × 10 × 1 mm) from the remaining 71 BCS patients were included in a blinded reader study, which resulted in 69.0% sensitivity and 79.0% specificity using OCT images, versus 92.9% sensitivity and 96.4% specificity using elasticity images. The quantitative nature of QME also facilitated development of an automated reader, which resulted in 100.0% sensitivity and 97.7% specificity. These results demonstrate high accuracy of QME for detecting tumor within 1 mm of the margin and the potential for this technique to improve outcomes in BCS. Significance : An optical imaging technology probes breast tissue elasticity to provide accurate assessment of tumor margin involvement in breast-conserving surgery. | |
dc.format.extent | 11 | |
dc.format.extent | 1118883 | |
dc.language.iso | eng | |
dc.relation.ispartof | Cancer Research | en |
dc.subject | Breast-conserving surgery | en |
dc.subject | Surgical guidance | en |
dc.subject | Tumor margins | en |
dc.subject | Elastography | en |
dc.subject | RC0254 Neoplasms. Tumors. Oncology (including Cancer) | en |
dc.subject | RD Surgery | en |
dc.subject | E-NDAS | en |
dc.subject | SDG 3 - Good Health and Well-being | en |
dc.subject.lcc | RC0254 | en |
dc.subject.lcc | RD | en |
dc.title | Diagnostic accuracy of quantitative micro-elastography for margin assessment in breast-conserving surgery | en |
dc.type | Journal article | en |
dc.contributor.institution | University of St Andrews. School of Physics and Astronomy | en |
dc.identifier.doi | 10.1158/0008-5472.CAN-19-1240 | |
dc.description.status | Peer reviewed | en |
dc.date.embargoedUntil | 2021-04-15 |
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