St Andrews Research Repository

St Andrews University Home
View Item 
  •   St Andrews Research Repository
  • University of St Andrews Research
  • University of St Andrews Research
  • University of St Andrews Research
  • View Item
  •   St Andrews Research Repository
  • University of St Andrews Research
  • University of St Andrews Research
  • University of St Andrews Research
  • View Item
  •   St Andrews Research Repository
  • University of St Andrews Research
  • University of St Andrews Research
  • University of St Andrews Research
  • View Item
  • Login
JavaScript is disabled for your browser. Some features of this site may not work without it.

Contrasting roles for DNA methyltransferases and histone deacetylases in single-item and associative recognition memory

Thumbnail
View/Open
Scott_2020_Contrastingroles_CC.pdf (674.6Kb)
Date
06/03/2017
Author
Scott, Hannah
Smith, Anna E.
Barker, Gareth R.
Uney, James B.
Warburton, E. Clea
Keywords
DNMT
HDAC
Hippocampus
Perirhinal cortex
Prefrontal cortex
Recognition memory
RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Biochemistry
Developmental Neuroscience
Cognitive Neuroscience
Cellular and Molecular Neuroscience
Biological Psychiatry
NDAS
Metadata
Show full item record
Altmetrics Handle Statistics
Altmetrics DOI Statistics
Abstract
Recognition memory enables us to judge whether we have encountered a stimulus before and to recall associated information, including where the stimulus was encountered. The perirhinal cortex (PRh) is required for judgment of stimulus familiarity, while hippocampus (HPC) and medial prefrontal cortex (mPFC) are additionally involved when spatial information associated with a stimulus needs to be remembered. While gene expression is known to be essential for the consolidation of long-term recognition memory, the underlying regulatory mechanisms are not fully understood. Here we investigated the roles of two epigenetic mechanisms, DNA methylation and histone deacetylation, in recognition memory. Infusion of DNA methyltransferase inhibitors into PRh impaired performance in novel object recognition and object-in-place tasks while infusions into HPC or mPFC impaired object-in-place performance only. In contrast, inhibition of histone deacetylases in PRh, but not mPFC, enhanced recognition memory. These results support the emerging role of epigenetic processes in learning and memory.
Citation
Scott , H , Smith , A E , Barker , G R , Uney , J B & Warburton , E C 2017 , ' Contrasting roles for DNA methyltransferases and histone deacetylases in single-item and associative recognition memory ' , Neuroepigenetics , vol. 9 , pp. 1-9 . https://doi.org/10.1016/j.nepig.2017.02.001
Publication
Neuroepigenetics
Status
Peer reviewed
DOI
https://doi.org/10.1016/j.nepig.2017.02.001
ISSN
2214-7845
Type
Journal article
Rights
Copyright © 2017 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Description
This work was supported by the Biotechnology and Biological Sciences Research Council (BBSRC) [grant number BB/I00310X/1]. HS and AES were supported by Medical Research Council (MRC) Doctoral Training Grants
Collections
  • University of St Andrews Research
URI
http://hdl.handle.net/10023/20502

Items in the St Andrews Research Repository are protected by copyright, with all rights reserved, unless otherwise indicated.

Advanced Search

Browse

All of RepositoryCommunities & CollectionsBy Issue DateNamesTitlesSubjectsClassificationTypeFunderThis CollectionBy Issue DateNamesTitlesSubjectsClassificationTypeFunder

My Account

Login

Open Access

To find out how you can benefit from open access to research, see our library web pages and Open Access blog. For open access help contact: openaccess@st-andrews.ac.uk.

Accessibility

Read our Accessibility statement.

How to submit research papers

The full text of research papers can be submitted to the repository via Pure, the University's research information system. For help see our guide: How to deposit in Pure.

Electronic thesis deposit

Help with deposit.

Repository help

For repository help contact: Digital-Repository@st-andrews.ac.uk.

Give Feedback

Cookie policy

This site may use cookies. Please see Terms and Conditions.

Usage statistics

COUNTER-compliant statistics on downloads from the repository are available from the IRUS-UK Service. Contact us for information.

© University of St Andrews Library

University of St Andrews is a charity registered in Scotland, No SC013532.

  • Facebook
  • Twitter