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dc.contributor.authorScott, Hannah
dc.contributor.authorSmith, Anna E.
dc.contributor.authorBarker, Gareth R.
dc.contributor.authorUney, James B.
dc.contributor.authorWarburton, E. Clea
dc.date.accessioned2020-08-24T08:30:01Z
dc.date.available2020-08-24T08:30:01Z
dc.date.issued2017-03-06
dc.identifier.citationScott , H , Smith , A E , Barker , G R , Uney , J B & Warburton , E C 2017 , ' Contrasting roles for DNA methyltransferases and histone deacetylases in single-item and associative recognition memory ' , Neuroepigenetics , vol. 9 , pp. 1-9 . https://doi.org/10.1016/j.nepig.2017.02.001en
dc.identifier.issn2214-7845
dc.identifier.otherPURE: 269725070
dc.identifier.otherPURE UUID: 879c6dd5-c9b0-4f9f-a41f-0e91dd40abfc
dc.identifier.otherScopus: 85015100121
dc.identifier.otherORCID: /0000-0003-1438-2663/work/79227026
dc.identifier.urihttp://hdl.handle.net/10023/20502
dc.descriptionThis work was supported by the Biotechnology and Biological Sciences Research Council (BBSRC) [grant number BB/I00310X/1]. HS and AES were supported by Medical Research Council (MRC) Doctoral Training Grantsen
dc.description.abstractRecognition memory enables us to judge whether we have encountered a stimulus before and to recall associated information, including where the stimulus was encountered. The perirhinal cortex (PRh) is required for judgment of stimulus familiarity, while hippocampus (HPC) and medial prefrontal cortex (mPFC) are additionally involved when spatial information associated with a stimulus needs to be remembered. While gene expression is known to be essential for the consolidation of long-term recognition memory, the underlying regulatory mechanisms are not fully understood. Here we investigated the roles of two epigenetic mechanisms, DNA methylation and histone deacetylation, in recognition memory. Infusion of DNA methyltransferase inhibitors into PRh impaired performance in novel object recognition and object-in-place tasks while infusions into HPC or mPFC impaired object-in-place performance only. In contrast, inhibition of histone deacetylases in PRh, but not mPFC, enhanced recognition memory. These results support the emerging role of epigenetic processes in learning and memory.
dc.format.extent9
dc.language.isoeng
dc.relation.ispartofNeuroepigeneticsen
dc.rightsCopyright © 2017 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).en
dc.subjectDNMTen
dc.subjectHDACen
dc.subjectHippocampusen
dc.subjectPerirhinal cortexen
dc.subjectPrefrontal cortexen
dc.subjectRecognition memoryen
dc.subjectRC0321 Neuroscience. Biological psychiatry. Neuropsychiatryen
dc.subjectBiochemistryen
dc.subjectDevelopmental Neuroscienceen
dc.subjectCognitive Neuroscienceen
dc.subjectCellular and Molecular Neuroscienceen
dc.subjectBiological Psychiatryen
dc.subjectNDASen
dc.subject.lccRC0321en
dc.titleContrasting roles for DNA methyltransferases and histone deacetylases in single-item and associative recognition memoryen
dc.typeJournal articleen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews.School of Psychology and Neuroscienceen
dc.identifier.doihttps://doi.org/10.1016/j.nepig.2017.02.001
dc.description.statusPeer revieweden


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