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Purifying selection in corvids is less efficient on islands

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Kutschera_2019_MBE_Purifying_CC.pdf (530.3Kb)
Date
02/2020
Author
Kutschera, Verena E.
Poelstra, Jelmer W.
Botero-Castro, Fidel
Dussex, Nicolas
Gemmell, Neil J.
Hunt, Gavin R.
Ritchie, Michael G.
Rutz, Christian
Wiberg, R. Axel W.
Wolf, Jochen B.W.
Funder
BBSRC
Grant ID
BB/G023913/2
Keywords
Avian genomics
Comparative analysis
Distribution of fitness effects
Molecular evolution
Mutation load
Selection
Ecology, Evolution, Behavior and Systematics
Molecular Biology
Genetics
DAS
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Abstract
Theory predicts that deleterious mutations accumulate more readily in small populations. As a consequence, mutation load is expected to be elevated in species where life-history strategies and geographic or historical contingencies reduce the number of reproducing individuals. Yet, few studies have empirically tested this prediction using genome-wide data in a comparative framework. We collected whole-genome sequencing data for 147 individuals across seven crow species (Corvus spp.). For each species, we estimated the distribution of fitness effects of deleterious mutations and compared it with proxies of the effective population size Ne. Island species with comparatively smaller geographic range sizes had a significantly increased mutation load. These results support the view that small populations have an elevated risk of mutational meltdown, which may contribute to the higher extinction rates observed in island species.
Citation
Kutschera , V E , Poelstra , J W , Botero-Castro , F , Dussex , N , Gemmell , N J , Hunt , G R , Ritchie , M G , Rutz , C , Wiberg , R A W & Wolf , J B W 2020 , ' Purifying selection in corvids is less efficient on islands ' , Molecular Biology and Evolution , vol. 37 , no. 2 , pp. 469-474 . https://doi.org/10.1093/molbev/msz233
Publication
Molecular Biology and Evolution
Status
Peer reviewed
DOI
https://doi.org/10.1093/molbev/msz233
ISSN
0737-4038
Type
Journal article
Rights
Copyright © The Author(s) 2019. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
Description
Funding was provided by the European Research Council (ERCStG-336536 FuncSpecGen to J.B.W.W.), the Swedish Research Council Vetenskapsrådet (621-2013-4510 to J.B.W.W.), the Knut and Alice Wallenberg Foundation (to J.B.W.W.), the Lawski foundation (to V.E.K. and J.B.W.W.), the German Research Foundation (KU 3402/1-1 to V.E.K.), the UK’s Biotechnology and Biological Sciences Research Council (BB/G023913/2 to C.R.), and the New Zealand Marsden Fund (to G.R.H.).
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  • University of St Andrews Research
URI
http://hdl.handle.net/10023/19463

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