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dc.contributor.authorKutschera, Verena E.
dc.contributor.authorPoelstra, Jelmer W.
dc.contributor.authorBotero-Castro, Fidel
dc.contributor.authorDussex, Nicolas
dc.contributor.authorGemmell, Neil J.
dc.contributor.authorHunt, Gavin R.
dc.contributor.authorRitchie, Michael G.
dc.contributor.authorRutz, Christian
dc.contributor.authorWiberg, R. Axel W.
dc.contributor.authorWolf, Jochen B.W.
dc.date.accessioned2020-02-14T11:30:13Z
dc.date.available2020-02-14T11:30:13Z
dc.date.issued2020-02
dc.identifier.citationKutschera , V E , Poelstra , J W , Botero-Castro , F , Dussex , N , Gemmell , N J , Hunt , G R , Ritchie , M G , Rutz , C , Wiberg , R A W & Wolf , J B W 2020 , ' Purifying selection in corvids is less efficient on islands ' , Molecular Biology and Evolution , vol. 37 , no. 2 , pp. 469-474 . https://doi.org/10.1093/molbev/msz233en
dc.identifier.issn0737-4038
dc.identifier.otherPURE: 266390213
dc.identifier.otherPURE UUID: 8ba6c010-0750-4c2e-a550-cb525b8a3e9c
dc.identifier.otherScopus: 85078869460
dc.identifier.otherPubMed: 31633794
dc.identifier.otherORCID: /0000-0001-7913-8675/work/69029136
dc.identifier.otherORCID: /0000-0001-5187-7417/work/69029264
dc.identifier.otherWOS: 000518533800014
dc.identifier.urihttps://hdl.handle.net/10023/19463
dc.descriptionFunding was provided by the European Research Council (ERCStG-336536 FuncSpecGen to J.B.W.W.), the Swedish Research Council Vetenskapsrådet (621-2013-4510 to J.B.W.W.), the Knut and Alice Wallenberg Foundation (to J.B.W.W.), the Lawski foundation (to V.E.K. and J.B.W.W.), the German Research Foundation (KU 3402/1-1 to V.E.K.), the UK’s Biotechnology and Biological Sciences Research Council (BB/G023913/2 to C.R.), and the New Zealand Marsden Fund (to G.R.H.).en
dc.description.abstractTheory predicts that deleterious mutations accumulate more readily in small populations. As a consequence, mutation load is expected to be elevated in species where life-history strategies and geographic or historical contingencies reduce the number of reproducing individuals. Yet, few studies have empirically tested this prediction using genome-wide data in a comparative framework. We collected whole-genome sequencing data for 147 individuals across seven crow species (Corvus spp.). For each species, we estimated the distribution of fitness effects of deleterious mutations and compared it with proxies of the effective population size Ne. Island species with comparatively smaller geographic range sizes had a significantly increased mutation load. These results support the view that small populations have an elevated risk of mutational meltdown, which may contribute to the higher extinction rates observed in island species.
dc.format.extent6
dc.language.isoeng
dc.relation.ispartofMolecular Biology and Evolutionen
dc.rightsCopyright © The Author(s) 2019. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.comen
dc.subjectAvian genomicsen
dc.subjectComparative analysisen
dc.subjectDistribution of fitness effectsen
dc.subjectMolecular evolutionen
dc.subjectMutation loaden
dc.subjectSelectionen
dc.subjectEcology, Evolution, Behavior and Systematicsen
dc.subjectMolecular Biologyen
dc.subjectGeneticsen
dc.subjectDASen
dc.titlePurifying selection in corvids is less efficient on islandsen
dc.typeJournal articleen
dc.contributor.sponsorBBSRCen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews. School of Biologyen
dc.contributor.institutionUniversity of St Andrews. Centre for Biological Diversityen
dc.contributor.institutionUniversity of St Andrews. Institute of Behavioural and Neural Sciencesen
dc.contributor.institutionUniversity of St Andrews. Centre for Social Learning & Cognitive Evolutionen
dc.identifier.doihttps://doi.org/10.1093/molbev/msz233
dc.description.statusPeer revieweden
dc.identifier.grantnumberBB/G023913/2en


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