Files in this item
N-Alkyl-α-amino acids in Nature and their biocatalytic preparation
Item metadata
dc.contributor.author | Hyslop, Julia F. | |
dc.contributor.author | Lovelock, Sarah L. | |
dc.contributor.author | Watson, Allan J. B. | |
dc.contributor.author | Sutton, Peter W. | |
dc.contributor.author | Roiban, Gheorghe-Doru | |
dc.date.accessioned | 2020-01-26T00:35:30Z | |
dc.date.available | 2020-01-26T00:35:30Z | |
dc.date.issued | 2019-03-10 | |
dc.identifier | 257558736 | |
dc.identifier | 0de50719-e7e6-4a8d-b3fc-a4c79af44488 | |
dc.identifier | 85061179434 | |
dc.identifier | 000460015300007 | |
dc.identifier.citation | Hyslop , J F , Lovelock , S L , Watson , A J B , Sutton , P W & Roiban , G-D 2019 , ' N -Alkyl-α-amino acids in Nature and their biocatalytic preparation ' , Journal of Biotechnology , vol. 293 , pp. 56-65 . https://doi.org/10.1016/j.jbiotec.2019.01.006 | en |
dc.identifier.issn | 0168-1656 | |
dc.identifier.other | RIS: urn:A6139A4984A27C9E4BA093DF9BFD239C | |
dc.identifier.other | ORCID: /0000-0002-1582-4286/work/56639160 | |
dc.identifier.uri | https://hdl.handle.net/10023/19355 | |
dc.description | PWS would like to acknowledge the European Union for his current funding: “This project has received funding from the European Union’s Horizon 2020 research and innovation programme under Marie Skłodowska-Curie grant agreement No 665919”. | en |
dc.description.abstract | N-alkylated-α-amino acids are useful building blocks for the pharmaceutical and fine chemical industries. Enantioselective methods of N-alkylated-α-amino acid synthesis are therefore highly valuable and widely investigated. While there are a variety of chemical methods for their synthesis, they often employ stoichiometric quantities of hazardous reagents such as pyrophoric metal hydrides or genotoxic alkylating agents, whereas biocatalytic routes can provide a greener and cleaner alternative to existing methods. This review highlights the occurrence of the N-alkyl-α-amino acid motif and its role in nature, important applications towards human health and biocatalytic methods of preparation. Several enzyme classes that can be used to access chiral N-alkylated-α-amino acids and their substrate selectivities are detailed. | |
dc.format.extent | 10 | |
dc.format.extent | 763491 | |
dc.language.iso | eng | |
dc.relation.ispartof | Journal of Biotechnology | en |
dc.subject | N-Alkyl-α-amino acids | en |
dc.subject | Biocatalysis | en |
dc.subject | N-Methyl transferases | en |
dc.subject | Dehydrogenases | en |
dc.subject | QD Chemistry | en |
dc.subject | T-NDAS | en |
dc.subject | SDG 3 - Good Health and Well-being | en |
dc.subject.lcc | QD | en |
dc.title | N-Alkyl-α-amino acids in Nature and their biocatalytic preparation | en |
dc.type | Journal article | en |
dc.contributor.institution | University of St Andrews. School of Chemistry | en |
dc.identifier.doi | 10.1016/j.jbiotec.2019.01.006 | |
dc.description.status | Peer reviewed | en |
dc.date.embargoedUntil | 2020-01-26 |
This item appears in the following Collection(s)
Items in the St Andrews Research Repository are protected by copyright, with all rights reserved, unless otherwise indicated.