N-Alkyl-α-amino acids in Nature and their biocatalytic preparation
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N-alkylated-α-amino acids are useful building blocks for the pharmaceutical and fine chemical industries. Enantioselective methods of N-alkylated-α-amino acid synthesis are therefore highly valuable and widely investigated. While there are a variety of chemical methods for their synthesis, they often employ stoichiometric quantities of hazardous reagents such as pyrophoric metal hydrides or genotoxic alkylating agents, whereas biocatalytic routes can provide a greener and cleaner alternative to existing methods. This review highlights the occurrence of the N-alkyl-α-amino acid motif and its role in nature, important applications towards human health and biocatalytic methods of preparation. Several enzyme classes that can be used to access chiral N-alkylated-α-amino acids and their substrate selectivities are detailed.
Hyslop , J F , Lovelock , S L , Watson , A J B , Sutton , P W & Roiban , G-D 2019 , ' N -Alkyl-α-amino acids in Nature and their biocatalytic preparation ' , Journal of Biotechnology , vol. 293 , pp. 56-65 . https://doi.org/10.1016/j.jbiotec.2019.01.006
Journal of Biotechnology
Copyright © 2019 Elsevier B.V. All rights reserved. This work has been made available online in accordance with the publisher’s policies. This is the author created, accepted version manuscript following peer review and may differ slightly from the final published version. The final published version of this work is available at https://doi.org/10.1016/j.jbiotec.2019.01.006
DescriptionPWS would like to acknowledge the European Union for his current funding: “This project has received funding from the European Union’s Horizon 2020 research and innovation programme under Marie Skłodowska-Curie grant agreement No 665919”.
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