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Perceptions of research bronchoscopy in Malawian adults with pulmonary tuberculosis : a cross-sectional study

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McCallum_2019_Perceptions_of_research_PONE_e0165734.PDF (1.389Mb)
Date
31/10/2016
Author
McCallum, Andrew D.
Nyirenda, Deborah
Lora, Wezzie
Khoo, Saye H.
Sloan, Derek J.
Mwandumba, Henry C.
Desmond, Nicola
Davies, Geraint R.
Keywords
RA Public aspects of medicine
RD Surgery
RM Therapeutics. Pharmacology
Agricultural and Biological Sciences(all)
Biochemistry, Genetics and Molecular Biology(all)
NDAS
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Abstract
Bronchoscopy is an established research tool in Malawi, enabling collection of pulmonary samples for immunological, pharmacological, and microbiological studies. It is, however, an invasive clinical procedure that offers no direct benefit to volunteering participants when used in a research capacity alone, and thus informed consent is essential. This study aimed to explore TB patients' understanding of research bronchoscopy, what would motivate them to participate in research bronchoscopy, and their concerns, in order to inform consenting processes for future clinical studies. We used a qualitative research design. Two focus group discussions were conducted with community members and TB patients to understand their perceptions of bronchoscopy. Transcripts were coded by multiple coauthors and thematic content analysis was used to analyse main findings. We found that Malawian patients with pulmonary TB were willing to participate in a study using research bronchoscopy for health assessment and access to improved healthcare. We identified information of value to potential participants when consenting to that may lessen some of the anxieties expressed by participants. Patient and public involvement is essential to improve informed consent and institutional trust.
Citation
McCallum , A D , Nyirenda , D , Lora , W , Khoo , S H , Sloan , D J , Mwandumba , H C , Desmond , N & Davies , G R 2016 , ' Perceptions of research bronchoscopy in Malawian adults with pulmonary tuberculosis : a cross-sectional study ' , PLoS ONE , vol. 11 , no. 10 , e0165734 , pp. 1-12 . https://doi.org/10.1371/journal.pone.0165734
Publication
PLoS ONE
Status
Peer reviewed
DOI
https://doi.org/10.1371/journal.pone.0165734
ISSN
1932-6203
Type
Journal article
Rights
Copyright :© 2016 McCallum et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Description
Funding: Liverpool Integrated Clinical Academic Training Programme, experience at another institution (ADM); Wellcome Trust Clinical PhD Fellowship 105392/B/14/Z.
Collections
  • University of St Andrews Research
URI
http://hdl.handle.net/10023/18882

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