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dc.contributor.authorMcCallum, Andrew D.
dc.contributor.authorNyirenda, Deborah
dc.contributor.authorLora, Wezzie
dc.contributor.authorKhoo, Saye H.
dc.contributor.authorSloan, Derek J.
dc.contributor.authorMwandumba, Henry C.
dc.contributor.authorDesmond, Nicola
dc.contributor.authorDavies, Geraint R.
dc.date.accessioned2019-11-07T16:30:14Z
dc.date.available2019-11-07T16:30:14Z
dc.date.issued2016-10-31
dc.identifier.citationMcCallum , A D , Nyirenda , D , Lora , W , Khoo , S H , Sloan , D J , Mwandumba , H C , Desmond , N & Davies , G R 2016 , ' Perceptions of research bronchoscopy in Malawian adults with pulmonary tuberculosis : a cross-sectional study ' , PLoS ONE , vol. 11 , no. 10 , e0165734 , pp. 1-12 . https://doi.org/10.1371/journal.pone.0165734en
dc.identifier.issn1932-6203
dc.identifier.otherPURE: 262877333
dc.identifier.otherPURE UUID: b96ff7d5-d512-472a-9e4b-2b5d975bec8b
dc.identifier.otherScopus: 84993949279
dc.identifier.otherPubMed: 27792765
dc.identifier.otherORCID: /0000-0002-7888-5449/work/64361368
dc.identifier.urihttps://hdl.handle.net/10023/18882
dc.descriptionFunding: Liverpool Integrated Clinical Academic Training Programme, experience at another institution (ADM); Wellcome Trust Clinical PhD Fellowship 105392/B/14/Z.en
dc.description.abstractBronchoscopy is an established research tool in Malawi, enabling collection of pulmonary samples for immunological, pharmacological, and microbiological studies. It is, however, an invasive clinical procedure that offers no direct benefit to volunteering participants when used in a research capacity alone, and thus informed consent is essential. This study aimed to explore TB patients' understanding of research bronchoscopy, what would motivate them to participate in research bronchoscopy, and their concerns, in order to inform consenting processes for future clinical studies. We used a qualitative research design. Two focus group discussions were conducted with community members and TB patients to understand their perceptions of bronchoscopy. Transcripts were coded by multiple coauthors and thematic content analysis was used to analyse main findings. We found that Malawian patients with pulmonary TB were willing to participate in a study using research bronchoscopy for health assessment and access to improved healthcare. We identified information of value to potential participants when consenting to that may lessen some of the anxieties expressed by participants. Patient and public involvement is essential to improve informed consent and institutional trust.
dc.format.extent12
dc.language.isoeng
dc.relation.ispartofPLoS ONEen
dc.rightsCopyright :© 2016 McCallum et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en
dc.subjectRA Public aspects of medicineen
dc.subjectRD Surgeryen
dc.subjectRM Therapeutics. Pharmacologyen
dc.subjectAgricultural and Biological Sciences(all)en
dc.subjectBiochemistry, Genetics and Molecular Biology(all)en
dc.subjectNDASen
dc.subjectSDG 3 - Good Health and Well-beingen
dc.subject.lccRAen
dc.subject.lccRDen
dc.subject.lccRMen
dc.titlePerceptions of research bronchoscopy in Malawian adults with pulmonary tuberculosis : a cross-sectional studyen
dc.typeJournal articleen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews. School of Medicineen
dc.identifier.doihttps://doi.org/10.1371/journal.pone.0165734
dc.description.statusPeer revieweden


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