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Effect of psychological intervention on fear of cancer recurrence : a systematic review and meta-analysis

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Date
18/09/2019
Author
Tauber, Nina M.
O'Toole, Mia S.
Dinkel, Andreas
Galica, Jacqueline
Humphris, Gerry
Lebel, Sophie
Maheu, Christine
Ozakinci, Gozde
Prins, Judith
Sharpe, Louise
Smith, Allan 'Ben'
Thewes, Belinda
Simard, Sébastien
Zachariae, Robert
Keywords
BF Psychology
RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Metadata
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Abstract
Purpose Fear of cancer recurrence (FCR) is a significantly distressing problem that affects a substantial number of patients with and survivors of cancer; however, the overall efficacy of available psychological interventions on FCR remains unknown. We therefore evaluated this in the present systematic review and meta-analysis. Methods We searched key electronic databases to identify trials that evaluated the effect of psychological interventions on FCR among patients with and survivors of cancer. Controlled trials were subjected to meta-analysis, and the moderating influence of study characteristics on the effect were examined. Overall quality of evidence was evaluated using the GRADE system. Open trials were narratively reviewed to explore ongoing developments in the field (PROSPERO registration no.: CRD42017076514). Results A total of 23 controlled trials (21 randomized controlled trials) and nine open trials were included. Small effects (Hedges’s g) were found both at postintervention (g = 0.33; 95% CI, 0.20 to 0.46; P < .001) and at follow-up (g = 0.28; 95% CI, 0.17 to 0.40; P < .001). Effects at postintervention of contemporary cognitive behavioral therapies (CBTs; g = 0.42) were larger than those of traditional CBTs (g = 0.24; β = .22; 95% CI, .04 to .41; P = .018). At follow-up, larger effects were associated with shorter time to follow-up (β = −.01; 95% CI, −.01 to −.00; P = .027) and group-based formats (β = .18; 95% CI, .01 to .36; P = .041). A GRADE evaluation indicated evidence of moderate strength for effects of psychological intervention for FCR. Conclusion Psychological interventions for FCR revealed a small but robust effect at postintervention, which was largely maintained at follow-up. Larger postintervention effects were found for contemporary CBTs that were focused on processes of cognition—for example, worry, rumination, and attentional bias—rather than the content, and aimed to change the way in which the individual relates to his or her inner experiences. Future trials could investigate how to further optimize and tailor interventions to individual patients’ FCR presentation.
Citation
Tauber , N M , O'Toole , M S , Dinkel , A , Galica , J , Humphris , G , Lebel , S , Maheu , C , Ozakinci , G , Prins , J , Sharpe , L , Smith , A B , Thewes , B , Simard , S & Zachariae , R 2019 , ' Effect of psychological intervention on fear of cancer recurrence : a systematic review and meta-analysis ' , Journal of Clinical Oncology , vol. 37 . https://doi.org/10.1200/JCO.19.00572
Publication
Journal of Clinical Oncology
Status
Peer reviewed
DOI
https://doi.org/10.1200/JCO.19.00572
ISSN
0732-183X
Type
Journal item
Rights
Copyright © 2019 by American Society of Clinical Oncology. Licensed under the Creative Commons Attribution 4.0 license.
Description
The study was supported in part by the Danish Cancer Society, Grant# R150-A10080
Collections
  • University of St Andrews Research
URI
http://hdl.handle.net/10023/18507

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