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Gene exchange drives the ecological success of a multi-host bacterial pathogen

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Richardson_et_al_accepted.pdf (492.9Kb)
Date
09/2018
Author
Richardson, Emily J
Bacigalupe, Rodrigo
Harrison, Ewan M
Weinert, Lucy A
Lycett, Samantha
Vrieling, Manouk
Robb, Kirsty
Hoskisson, Paul A
Holden, Matthew T G
Feil, Edward J
Paterson, Gavin K
Tong, Steven Y C
Shittu, Adebayo
van Wamel, Willem
Aanensen, David M
Parkhill, Julian
Peacock, Sharon J
Corander, Jukka
Holmes, Mark
Fitzgerald, J Ross
Keywords
Staphylococcus aureus
Host-species
Adaptation
Genomics
QR Microbiology
DAS
BDC
R2C
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Abstract
The capacity for some pathogens to jump into different host-species populations is a major threat to public health and food security. Staphylococcus aureus is a multi-host bacterial pathogen responsible for important human and livestock diseases. Here, using a population-genomic approach, we identify humans as a major hub for ancient and recent S. aureus host-switching events linked to the emergence of endemic livestock strains, and cows as the main animal reservoir for the emergence of human epidemic clones. Such host-species transitions are associated with horizontal acquisition of genetic elements from host-specific gene pools conferring traits required for survival in the new host-niche. Importantly, genes associated with antimicrobial resistance are unevenly distributed among human and animal hosts, reflecting distinct antibiotic usage practices in medicine and agriculture. In addition to gene acquisition, genetic diversification has occurred in pathways associated with nutrient acquisition, implying metabolic remodelling after a host switch in response to distinct nutrient availability. For example, S. aureus from dairy cattle exhibit enhanced utilization of lactose-a major source of carbohydrate in bovine milk. Overall, our findings highlight the influence of human activities on the multi-host ecology of a major bacterial pathogen, underpinned by horizontal gene transfer and core genome diversification.
Citation
Richardson , E J , Bacigalupe , R , Harrison , E M , Weinert , L A , Lycett , S , Vrieling , M , Robb , K , Hoskisson , P A , Holden , M T G , Feil , E J , Paterson , G K , Tong , S Y C , Shittu , A , van Wamel , W , Aanensen , D M , Parkhill , J , Peacock , S J , Corander , J , Holmes , M & Fitzgerald , J R 2018 , ' Gene exchange drives the ecological success of a multi-host bacterial pathogen ' , Nature Ecology and Evolution , vol. 2 , no. 9 , pp. 1468-1478 . https://doi.org/10.1038/s41559-018-0617-0
Publication
Nature Ecology and Evolution
Status
Peer reviewed
DOI
https://doi.org/10.1038/s41559-018-0617-0
ISSN
2397-334X
Type
Journal article
Rights
© 2018, the Author(s). This work has been made available online in accordance with the publisher’s policies. This is the final published version of the work, which was originally published at https://doi.org/10.1038/s41559-018-0617-0
Description
M.T.G.H. was supported by the Scottish Infection Research Network and Chief Scientist Office through Scottish Healthcare Associated Infection Prevention Institute consortium funding (CSO reference: SIRN10).
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  • University of St Andrews Research
URI
http://hdl.handle.net/10023/16918

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