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dc.contributor.authorRichardson, Emily J
dc.contributor.authorBacigalupe, Rodrigo
dc.contributor.authorHarrison, Ewan M
dc.contributor.authorWeinert, Lucy A
dc.contributor.authorLycett, Samantha
dc.contributor.authorVrieling, Manouk
dc.contributor.authorRobb, Kirsty
dc.contributor.authorHoskisson, Paul A
dc.contributor.authorHolden, Matthew T G
dc.contributor.authorFeil, Edward J
dc.contributor.authorPaterson, Gavin K
dc.contributor.authorTong, Steven Y C
dc.contributor.authorShittu, Adebayo
dc.contributor.authorvan Wamel, Willem
dc.contributor.authorAanensen, David M
dc.contributor.authorParkhill, Julian
dc.contributor.authorPeacock, Sharon J
dc.contributor.authorCorander, Jukka
dc.contributor.authorHolmes, Mark
dc.contributor.authorFitzgerald, J Ross
dc.identifier.citationRichardson , E J , Bacigalupe , R , Harrison , E M , Weinert , L A , Lycett , S , Vrieling , M , Robb , K , Hoskisson , P A , Holden , M T G , Feil , E J , Paterson , G K , Tong , S Y C , Shittu , A , van Wamel , W , Aanensen , D M , Parkhill , J , Peacock , S J , Corander , J , Holmes , M & Fitzgerald , J R 2018 , ' Gene exchange drives the ecological success of a multi-host bacterial pathogen ' , Nature Ecology and Evolution , vol. 2 , no. 9 , pp. 1468-1478 .
dc.identifier.otherPURE: 255190822
dc.identifier.otherPURE UUID: 65aad1df-8e30-4f38-8b11-03c4820ddd9e
dc.identifier.otherPubMed: 30038246
dc.identifier.otherScopus: 85050555990
dc.identifier.otherORCID: /0000-0002-4958-2166/work/60196363
dc.identifier.otherWOS: 000442468000025
dc.descriptionM.T.G.H. was supported by the Scottish Infection Research Network and Chief Scientist Office through Scottish Healthcare Associated Infection Prevention Institute consortium funding (CSO reference: SIRN10).en
dc.description.abstractThe capacity for some pathogens to jump into different host-species populations is a major threat to public health and food security. Staphylococcus aureus is a multi-host bacterial pathogen responsible for important human and livestock diseases. Here, using a population-genomic approach, we identify humans as a major hub for ancient and recent S. aureus host-switching events linked to the emergence of endemic livestock strains, and cows as the main animal reservoir for the emergence of human epidemic clones. Such host-species transitions are associated with horizontal acquisition of genetic elements from host-specific gene pools conferring traits required for survival in the new host-niche. Importantly, genes associated with antimicrobial resistance are unevenly distributed among human and animal hosts, reflecting distinct antibiotic usage practices in medicine and agriculture. In addition to gene acquisition, genetic diversification has occurred in pathways associated with nutrient acquisition, implying metabolic remodelling after a host switch in response to distinct nutrient availability. For example, S. aureus from dairy cattle exhibit enhanced utilization of lactose-a major source of carbohydrate in bovine milk. Overall, our findings highlight the influence of human activities on the multi-host ecology of a major bacterial pathogen, underpinned by horizontal gene transfer and core genome diversification.
dc.relation.ispartofNature Ecology and Evolutionen
dc.rights© 2018, the Author(s). This work has been made available online in accordance with the publisher’s policies. This is the final published version of the work, which was originally published at
dc.subjectStaphylococcus aureusen
dc.subjectQR Microbiologyen
dc.titleGene exchange drives the ecological success of a multi-host bacterial pathogenen
dc.typeJournal articleen
dc.contributor.institutionUniversity of St Andrews. School of Medicineen
dc.contributor.institutionUniversity of St Andrews. Infection and Global Health Divisionen
dc.contributor.institutionUniversity of St Andrews. Biomedical Sciences Research Complexen
dc.contributor.institutionUniversity of St Andrews. Infection Groupen
dc.description.statusPeer revieweden

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