Synthesis of next generation maleimide radical labels
Abstract
The synthesis and characterization of four new nitroxide-radical-containing next-generation maleimides are presented. Each new label has a single leaving group which is either a phenoxyl or bromide. The linker between the maleimide and the nitroxide-containing framework is either a racemic mixture of a short chain or an achiral longer chain. These molecules have been designed to site-specifically label vicinal cysteines in proteins for magnetic resonance studies. The characterization of the final products includes crystallography and the labeling of sperm whale myoglobin protein.
Citation
Hajjaj , B , Shah , A , Bell , S , Shirran , S L , Botting , C H , Slawin , A M Z , Hulme , A & Lovett , J E 2016 , ' Synthesis of next generation maleimide radical labels ' , Synlett , pp. 2357-2361 . https://doi.org/10.1055/s-0035-1562451
Publication
Synlett
Status
Peer reviewed
ISSN
0936-5214Type
Journal article
Description
This work was funded by EPSRC, Grant Number EP/LO22044/1, a Royal Society University Research Fellowship to JEL , Royal Society Research Grant RG120645 and support from Active Spectrum Inc.Collections
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