Synthesis of next generation maleimide radical labels
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The synthesis and characterization of four new nitroxide-radical-containing next-generation maleimides are presented. Each new label has a single leaving group which is either a phenoxyl or bromide. The linker between the maleimide and the nitroxide-containing framework is either a racemic mixture of a short chain or an achiral longer chain. These molecules have been designed to site-specifically label vicinal cysteines in proteins for magnetic resonance studies. The characterization of the final products includes crystallography and the labeling of sperm whale myoglobin protein.
Hajjaj , B , Shah , A , Bell , S , Shirran , S L , Botting , C H , Slawin , A M Z , Hulme , A & Lovett , J E 2016 , ' Synthesis of next generation maleimide radical labels ' Synlett , pp. 2357-2361 . DOI: 10.1055/s-0035-1562451
© 2016, Georg Thieme. This work is made available online in accordance with the publisher’s policies. This is the author created, accepted version manuscript following peer review and may differ slightly from the final published version. The final published version of this work is available at www.thieme-connect.de / https://dx.doi.org/10.1055/s-0035-1562451
This work was funded by EPSRC, Grant Number EP/LO22044/1, a Royal Society University Research Fellowship to JEL , Royal Society Research Grant RG120645 and support from Active Spectrum Inc.
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