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Synthesis of next generation maleimide radical labels
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dc.contributor.author | Hajjaj, Bouchra | |
dc.contributor.author | Shah, Anokhi | |
dc.contributor.author | Bell, Stacey | |
dc.contributor.author | Shirran, Sally Lorna | |
dc.contributor.author | Botting, Catherine Helen | |
dc.contributor.author | Slawin, Alexandra Martha Zoya | |
dc.contributor.author | Hulme, Alison | |
dc.contributor.author | Lovett, Janet Eleanor | |
dc.date.accessioned | 2017-07-05T23:33:38Z | |
dc.date.available | 2017-07-05T23:33:38Z | |
dc.date.issued | 2016-10 | |
dc.identifier | 243241620 | |
dc.identifier | 2015c6bd-6e3f-4d88-bf56-5d1aeae2a168 | |
dc.identifier | 84978935127 | |
dc.identifier | 000384468000010 | |
dc.identifier.citation | Hajjaj , B , Shah , A , Bell , S , Shirran , S L , Botting , C H , Slawin , A M Z , Hulme , A & Lovett , J E 2016 , ' Synthesis of next generation maleimide radical labels ' , Synlett , pp. 2357-2361 . https://doi.org/10.1055/s-0035-1562451 | en |
dc.identifier.issn | 0936-5214 | |
dc.identifier.other | ORCID: /0000-0003-3516-3507/work/32169103 | |
dc.identifier.other | ORCID: /0000-0002-3561-450X/work/40301304 | |
dc.identifier.other | ORCID: /0000-0002-9527-6418/work/56861939 | |
dc.identifier.uri | https://hdl.handle.net/10023/11153 | |
dc.description | This work was funded by EPSRC, Grant Number EP/LO22044/1, a Royal Society University Research Fellowship to JEL , Royal Society Research Grant RG120645 and support from Active Spectrum Inc. | en |
dc.description.abstract | The synthesis and characterization of four new nitroxide-radical-containing next-generation maleimides are presented. Each new label has a single leaving group which is either a phenoxyl or bromide. The linker between the maleimide and the nitroxide-containing framework is either a racemic mixture of a short chain or an achiral longer chain. These molecules have been designed to site-specifically label vicinal cysteines in proteins for magnetic resonance studies. The characterization of the final products includes crystallography and the labeling of sperm whale myoglobin protein. | |
dc.format.extent | 5 | |
dc.format.extent | 562423 | |
dc.language.iso | eng | |
dc.relation.ispartof | Synlett | en |
dc.subject | Next-generation maleimide | en |
dc.subject | Succinimide | en |
dc.subject | Nitroxide spin label | en |
dc.subject | Radical | en |
dc.subject | EPR spectroscopy | en |
dc.subject | QC Physics | en |
dc.subject | QD Chemistry | en |
dc.subject | DAS | en |
dc.subject.lcc | QC | en |
dc.subject.lcc | QD | en |
dc.title | Synthesis of next generation maleimide radical labels | en |
dc.type | Journal article | en |
dc.contributor.sponsor | EPSRC | en |
dc.contributor.sponsor | The Royal Society | en |
dc.contributor.institution | University of St Andrews. School of Physics and Astronomy | en |
dc.contributor.institution | University of St Andrews. School of Biology | en |
dc.contributor.institution | University of St Andrews. School of Chemistry | en |
dc.contributor.institution | University of St Andrews. EaSTCHEM | en |
dc.contributor.institution | University of St Andrews. Biomedical Sciences Research Complex | en |
dc.identifier.doi | 10.1055/s-0035-1562451 | |
dc.description.status | Peer reviewed | en |
dc.date.embargoedUntil | 2017-07-05 | |
dc.identifier.grantnumber | EP/L022044/1 | en |
dc.identifier.grantnumber | UF090121 | en |
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