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Synthesis of next generation maleimide radical labels

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dc.contributor.authorHajjaj, Bouchra
dc.contributor.authorShah, Anokhi
dc.contributor.authorBell, Stacey
dc.contributor.authorShirran, Sally Lorna
dc.contributor.authorBotting, Catherine Helen
dc.contributor.authorSlawin, Alexandra Martha Zoya
dc.contributor.authorHulme, Alison
dc.contributor.authorLovett, Janet Eleanor
dc.date.accessioned2017-07-05T23:33:38Z
dc.date.available2017-07-05T23:33:38Z
dc.date.issued2016-10
dc.identifier.citationHajjaj , B , Shah , A , Bell , S , Shirran , S L , Botting , C H , Slawin , A M Z , Hulme , A & Lovett , J E 2016 , ' Synthesis of next generation maleimide radical labels ' , Synlett , pp. 2357-2361 . https://doi.org/10.1055/s-0035-1562451en
dc.identifier.issn0936-5214
dc.identifier.otherPURE: 243241620
dc.identifier.otherPURE UUID: 2015c6bd-6e3f-4d88-bf56-5d1aeae2a168
dc.identifier.otherScopus: 84978935127
dc.identifier.otherORCID: /0000-0003-3516-3507/work/32169103
dc.identifier.otherORCID: /0000-0002-3561-450X/work/40301304
dc.identifier.otherORCID: /0000-0002-9527-6418/work/56861939
dc.identifier.otherWOS: 000384468000010
dc.identifier.urihttps://hdl.handle.net/10023/11153
dc.descriptionThis work was funded by EPSRC, Grant Number EP/LO22044/1, a Royal Society University Research Fellowship to JEL , Royal Society Research Grant RG120645 and support from Active Spectrum Inc.en
dc.description.abstractThe synthesis and characterization of four new nitroxide-radical-containing next-generation maleimides are presented. Each new label has a single leaving group which is either a phenoxyl or bromide. The linker between the maleimide and the nitroxide-containing framework is either a racemic mixture of a short chain or an achiral longer chain. These molecules have been designed to site-specifically label vicinal cysteines in proteins for magnetic resonance studies. The characterization of the final products includes crystallography and the labeling of sperm whale myoglobin protein.
dc.format.extent5
dc.language.isoeng
dc.relation.ispartofSynletten
dc.rights© 2016, Georg Thieme. This work is made available online in accordance with the publisher’s policies. This is the author created, accepted version manuscript following peer review and may differ slightly from the final published version. The final published version of this work is available at www.thieme-connect.de / https://dx.doi.org/10.1055/s-0035-1562451en
dc.subjectNext-generation maleimideen
dc.subjectSuccinimideen
dc.subjectNitroxide spin labelen
dc.subjectRadicalen
dc.subjectEPR spectroscopyen
dc.subjectQC Physicsen
dc.subjectQD Chemistryen
dc.subjectDASen
dc.subject.lccQCen
dc.subject.lccQDen
dc.titleSynthesis of next generation maleimide radical labelsen
dc.typeJournal articleen
dc.contributor.sponsorEPSRCen
dc.contributor.sponsorThe Royal Societyen
dc.description.versionPostprinten
dc.contributor.institutionUniversity of St Andrews. School of Physics and Astronomyen
dc.contributor.institutionUniversity of St Andrews. School of Biologyen
dc.contributor.institutionUniversity of St Andrews. School of Chemistryen
dc.contributor.institutionUniversity of St Andrews. EaSTCHEMen
dc.contributor.institutionUniversity of St Andrews. Biomedical Sciences Research Complexen
dc.identifier.doihttps://doi.org/10.1055/s-0035-1562451
dc.description.statusPeer revieweden
dc.date.embargoedUntil2017-07-05
dc.identifier.grantnumberEP/L022044/1en
dc.identifier.grantnumberUF090121en


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