Now showing items 1-11 of 11

    • Bunyamwera orthobunyavirus glycoprotein precursor is processed by cellular signal peptidase and signal peptide peptidase 

      Shi, Xiaohong; Botting, Catherine Helen; Li, Ping; Niglas, Mark; Brennan, Benjamin; Shirran, Sally Lorna; Szemiel, Agnieszka Marta; Elliott, Richard Michael (2016-08-02) - Journal article
      Bunyamwera virus (BUNV) is the prototype of the Orthobunyavirus genus and Bunyaviridae family that contains important human and animal pathogens. The cleavage mechanism of orthobunyavirus glycoprotein precursor (GPC) and ...
    • The cyanobactin heterocyclase enzyme : A processive adenylase that operates with a defined order of reaction 

      Koehnke, Jesko Alexander Johannes Gunter; Bent, Andrew Frank; Zollman, David; Smith, Kieran; Houssen, Wael E.; Zhu, Xiaofeng; Mann, Greg; Lebl, Tomas; Scharff, Richard; Shirran, Sally Lorna; Botting, Catherine Helen; Jaspers, Marcel; Schwarz-Linek, Uli; Naismith, Jim (2013-12) - Journal article
    • An internal thioester in a pathogen surface protein mediates covalent host binding 

      Walden, Miriam; Edwards, John Michael; Dziewulska, Aleksandra Malgorzata; Bergmann, Rene; Saalbach, Gerhard; Kan, Su-Yin; Miller, Ona Kealoha; Weckener, Miriam; Jackson, Rosemary J.; Shirran, Sally Lorna; Botting, Catherine Helen; Florence, Gordon John; Rohde, Manfred; Banfield, Mark J.; Schwarz-Linek, Uli (2015) - Journal article
      To cause disease and persist in a host, pathogenic and commensal microbes must adhere to tissues. Colonization and infection depend on specific molecular interactions at the host-microbe interface that involve microbial ...
    • On the interaction between human IQGAP1 and actin 

      Magill, Damian; Hamilton, Elaine; Shirran, Sally Lorna; Botting, Catherine Helen; Timson, David (2016) - Journal article
      IQGAPs are eukaryotic proteins which integrate signals from various sources and pass these on the cytoskeleton. Understanding how they do this requires information on the interfaces between the proteins. Here, it is shown ...
    • Quantitative proteomic changes in LPS-activated monocyte-derived dendritic cells : a SWATH-MS study 

      Arya, Swati; Wiatrek-Moumoulidis, Dagmara; Synowsky, Silvia Anna; Shirran, Sally Lorna; Botting, Catherine Helen; Powis, Simon John; Stewart, Alan James (2019-03-13) - Journal article
      Dendritic cells are key immune cells that respond to pathogens and co-ordinate many innate and adaptive immune responses. Quantitative mass spectrometry using Sequential Window Acquisition of all THeoretical fragment-ion ...
    • Rapid evolution and gene expression : a rapidly-evolving Mendelian trait that silences field crickets has widespread effects on mRNA and protein expression 

      Pascoal, Sonia Christina Marques; Liu, Xuan; Ly, Tony; Fang, Yongxiang; Rockliffe, Nichola; Paterson, Steve; Shirran, Sally Lorna; Botting, Catherine Helen; Bailey, Nathan William (2016-06) - Journal article
      A major advance in modern evolutionary biology is the ability to start linking phenotypic evolution in the wild with genomic changes that underlie that evolution. We capitalised on a rapidly-evolving Hawaiian population ...
    • A secretagogin locus of the mammalian hypothalamus controls stress hormone release 

      Romanov, Roman A.; Alpár, Alán; Zhang, Ming-Dong; Zeisel, Amit; Calas, André; Landry, Marc; Fuszard, Matthew Alexander; Shirran, Sally Lorna; Schnell, Robert; Dobolyi, Árpád; Oláh, Márk; Spence, Lauren; Mulder, Jan; Martens, Henrik; Palkovits, Miklós; Uhlen, Mathias; Sitte, Harald H.; Botting, Catherine Helen; Wagner, Ludwig; Linnarsson, Sten; Hökfelt, Tomas; Harkany, Tibor (2015-01-02) - Journal article
      A hierarchical hormonal cascade along the hypothalamic-pituitary-adrenal axis orchestrates bodily responses to stress. Although corticotropin-releasing hormone (CRH), produced by parvocellular neurons of the hypothalamic ...
    • Spinal muscular atrophy patient iPSC-derived motor neurons have reduced expression of proteins important in neuronal development 

      Fuller, Heidi; Mandefro, Berhan; Shirran, Sally Lorna; Gross, Andrew; Kaus, Anjoscha; Botting, Catherine Helen; Morris, Glen; Sareen, Dhruv (2016-01-11) - Journal article
      Spinal muscular atrophy (SMA) is an inherited neuromuscular disease primarily characterized by degeneration of spinal motor neurons, and caused by reduced levels of the SMN protein. Previous studies to understand the ...
    • Stathmin is enriched in the developing corticospinal tract 

      Fuller, Heidi; Slade, Robert; Jovanov-Milošević, Nataša; Babić, Mirjana; Sedmak, Goran; Šimić, Goran; Fuszard, Matthew Alexander; Shirran, Sally Lorna; Botting, Catherine Helen; Gates, Monte (2015) - Journal article
      Understanding the intra- and extracellular proteins involved in the development of the corticospinal tract (CST) may offer insights into how the pathway could be regenerated following traumatic spinal cord injury. Currently, ...
    • Structural analysis of leader peptide binding enables leader-free cyanobactin processing 

      Koehnke, Jesko Alexander Johannes Gunter; Mann, Greg; Bent, Andrew Frank; Ludewig, Hannes; Shirran, Sally Lorna; Botting, Catherine Helen; Lebl, Tomas; Houssen, Wael; Jaspers, Marcel; Naismith, Jim (2015-08) - Journal article
      Regioselective modification of amino acids within the context of a peptide is common to a number of biosynthetic pathways and many such products have potential as therapeutics. The ATP dependent enzyme LynD heterocyclizes ...
    • Synthesis of next generation maleimide radical labels 

      Hajjaj, Bouchra; Shah, Anokhi; Bell, Stacey; Shirran, Sally Lorna; Botting, Catherine Helen; Slawin, Alexandra Martha Zoya; Hulme, Alison; Lovett, Janet Eleanor (2016-10) - Journal article
      The synthesis and characterization of four new nitroxide-radical-containing next-generation maleimides are presented. Each new label has a single leaving group which is either a phenoxyl or bromide. The linker between the ...