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3T MRI investigation of cardiac left ventricular structure and function in a UK population : he Tayside screening for the prevention of cardiac events (TASCFORCE) study

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Date
11/2016
Author
Gandy, Stephen J.
Lambert, Matthew
Belch, Jill
Cavin, Ian
Crowe, Elena
Littleford, Roberta
MacFarlane, Jennifer A
Matthew, Shona Z
Martin, Patricia
Nicholas, R. Stephen
Struthers, Allan
Sullivan, Frank
Waugh, Shelley A.
White, Richard D.
Weir-McCall, Jonathan R.
Houston, J. Graeme
Keywords
Cardiac
MRI
3.0T
Left ventricle
Population
RA0421 Public health. Hygiene. Preventive Medicine
RC Internal medicine
NDAS
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Abstract
Purpose: To scan a volunteer population using 3.0T magnetic resonance imaging (MRI). MRI of the left ventricular (LV) structure and function in healthy volunteers has been reported extensively at 1.5T. Materials and Methods: A population of 1528 volunteers was scanned. A standardized approach was taken to acquire steady-state free precession (SSFP) LV data in the short-axis plane, and images were quantified using commercial software. Six observers undertook the segmentation analysis. Results: Mean values (±standard deviation, SD) were: ejection fraction (EF) = 69 ± 6%, end diastolic volume index (EDVI) = 71 ± 13 ml/m2 , end systolic volume index (ESVI) = 22 ± 7 ml/m2 , stroke volume index (SVI) = 49 ± 8 ml/m2 , and LV mass index (LVMI) = 55 ± 12 g/m2 . The mean EF was slightly larger for females (69%) than for males (68%), but all other variables were smaller for females (EDVI 68v77 ml/m2 , ESVI 21v25 ml/m2 , SVI 46v52 ml/m2 , LVMI 49v64 g/m2, all P < 0.05). The mean LV volume data mostly decreased with each age decade (EDVI males: -2.9 ± 1.3 ml/m2 , females: -3.1 ± 0.8 ml/m2 ; ESVI males: -1.3 ± 0.7 ml/m2 , females: -1.7 ± 0.5 ml/m2 ; SVI males: -1.7 ± 0.9 ml/m2 , females: -1.4 ± 0.6 ml/m2 ; LVMI males: -1.6 ± 1.1 g/m2 , females: -0.2 ± 0.6 g/m2 but the mean EF was virtually stable in males (0.6 ± 0.6%) and rose slightly in females (1.2 ± 0.5%) with age. Conclusion: LV reference ranges are provided in this population-based MR study at 3.0T. The variables are similar to those described at 1.5T, including variations with age and gender. These data may help to support future population-based MR research studies that involve the use of 3.0T MRI scanners.
Citation
Gandy , S J , Lambert , M , Belch , J , Cavin , I , Crowe , E , Littleford , R , MacFarlane , J A , Matthew , S Z , Martin , P , Nicholas , R S , Struthers , A , Sullivan , F , Waugh , S A , White , R D , Weir-McCall , J R & Houston , J G 2016 , ' 3T MRI investigation of cardiac left ventricular structure and function in a UK population : he Tayside screening for the prevention of cardiac events (TASCFORCE) study ' , Journal of Magnetic Resonance Imaging , vol. 44 , no. 5 , pp. 1186-1196 . https://doi.org/10.1002/jmri.25267
Publication
Journal of Magnetic Resonance Imaging
Status
Peer reviewed
DOI
https://doi.org/10.1002/jmri.25267
ISSN
1053-1807
Type
Journal article
Rights
© 2016 The Authors. Journal of Magnetic Resonance Imaging published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Description
Contract grant sponsor: Souter Charitable Trust, and Chest, Heart and Stroke Scotland; Contract grant sponsor: Wellcome Trust; contract grant number: WT 085664 (Clinical Research Fellowship to J.W-McC.)
Collections
  • Medicine Research
  • University of St Andrews Research
URI
http://hdl.handle.net/10023/10759

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