3T MRI investigation of cardiac left ventricular structure and function in a UK population : he Tayside screening for the prevention of cardiac events (TASCFORCE) study
Abstract
Purpose: To scan a volunteer population using 3.0T magnetic resonance imaging (MRI). MRI of the left ventricular (LV) structure and function in healthy volunteers has been reported extensively at 1.5T. Materials and Methods: A population of 1528 volunteers was scanned. A standardized approach was taken to acquire steady-state free precession (SSFP) LV data in the short-axis plane, and images were quantified using commercial software. Six observers undertook the segmentation analysis. Results: Mean values (±standard deviation, SD) were: ejection fraction (EF) = 69 ± 6%, end diastolic volume index (EDVI) = 71 ± 13 ml/m2 , end systolic volume index (ESVI) = 22 ± 7 ml/m2 , stroke volume index (SVI) = 49 ± 8 ml/m2 , and LV mass index (LVMI) = 55 ± 12 g/m2 . The mean EF was slightly larger for females (69%) than for males (68%), but all other variables were smaller for females (EDVI 68v77 ml/m2 , ESVI 21v25 ml/m2 , SVI 46v52 ml/m2 , LVMI 49v64 g/m2, all P < 0.05). The mean LV volume data mostly decreased with each age decade (EDVI males: -2.9 ± 1.3 ml/m2 , females: -3.1 ± 0.8 ml/m2 ; ESVI males: -1.3 ± 0.7 ml/m2 , females: -1.7 ± 0.5 ml/m2 ; SVI males: -1.7 ± 0.9 ml/m2 , females: -1.4 ± 0.6 ml/m2 ; LVMI males: -1.6 ± 1.1 g/m2 , females: -0.2 ± 0.6 g/m2 but the mean EF was virtually stable in males (0.6 ± 0.6%) and rose slightly in females (1.2 ± 0.5%) with age. Conclusion: LV reference ranges are provided in this population-based MR study at 3.0T. The variables are similar to those described at 1.5T, including variations with age and gender. These data may help to support future population-based MR research studies that involve the use of 3.0T MRI scanners.
Citation
Gandy , S J , Lambert , M , Belch , J , Cavin , I , Crowe , E , Littleford , R , MacFarlane , J A , Matthew , S Z , Martin , P , Nicholas , R S , Struthers , A , Sullivan , F , Waugh , S A , White , R D , Weir-McCall , J R & Houston , J G 2016 , ' 3T MRI investigation of cardiac left ventricular structure and function in a UK population : he Tayside screening for the prevention of cardiac events (TASCFORCE) study ' , Journal of Magnetic Resonance Imaging , vol. 44 , no. 5 , pp. 1186-1196 . https://doi.org/10.1002/jmri.25267
Publication
Journal of Magnetic Resonance Imaging
Status
Peer reviewed
ISSN
1053-1807Type
Journal article
Description
Contract grant sponsor: Souter Charitable Trust, and Chest, Heart and Stroke Scotland; Contract grant sponsor: Wellcome Trust; contract grant number: WT 085664 (Clinical Research Fellowship to J.W-McC.)Collections
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