Remarkable co-catalyst effects on the enantioselective hydrogenation of unfunctionalised enamines : both enantiomers of product from the same enantiomer of catalyst
Date
07/02/2016Metadata
Show full item recordAbstract
During studies on the enantioselective hydrogenation of unfunctionalised enamines, a very surprising switch in enantiopreference was observed; [((R,R)-Et-DUPHOS)-Rh(COD)]BF4 hydrogenates an enamine to give (R)-amine with up to 73% ee, but when iodine is added as a co-catalyst, the (S)-amine is formed with up to 61% ee. Mechanistic studies implicate a protonation-iminium ion reduction pathway.
Citation
Tin , S , Fanjul , T & Clarke , M L 2016 , ' Remarkable co-catalyst effects on the enantioselective hydrogenation of unfunctionalised enamines : both enantiomers of product from the same enantiomer of catalyst ' , Catalysis Science & Technology , vol. 6 , no. 3 , pp. 677-680 . https://doi.org/10.1039/C5CY02051D
Publication
Catalysis Science & Technology
Status
Peer reviewed
ISSN
2044-4753Type
Journal article
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