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Deep-brain photoreception links luminance detection to motor output in Xenopus frog tadpoles
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dc.contributor.author | Currie, Stephen Paul | |
dc.contributor.author | Doherty, Gayle Helane | |
dc.contributor.author | Sillar, Keith Thomas | |
dc.date.accessioned | 2016-11-11T00:33:52Z | |
dc.date.available | 2016-11-11T00:33:52Z | |
dc.date.issued | 2016-05-24 | |
dc.identifier | 242039229 | |
dc.identifier | 44279fb6-cca0-4c80-bb98-0e8928857419 | |
dc.identifier | 84969837269 | |
dc.identifier | 000376779900077 | |
dc.identifier.citation | Currie , S P , Doherty , G H & Sillar , K T 2016 , ' Deep-brain photoreception links luminance detection to motor output in Xenopus frog tadpoles ' , Proceedings of the National Academy of Sciences of the United States of America , vol. 113 , no. 21 , pp. 6053-6058 . https://doi.org/10.1073/pnas.1515516113 | en |
dc.identifier.issn | 0027-8424 | |
dc.identifier.other | ORCID: /0000-0003-3494-5857/work/60427296 | |
dc.identifier.other | ORCID: /0000-0003-0171-3814/work/64393768 | |
dc.identifier.uri | https://hdl.handle.net/10023/9803 | |
dc.description | SPC was supported by a BBSRC studentship. | en |
dc.description.abstract | Nonvisual photoreceptors are widely distributed in the retina and brain, but their roles in animal behavior remain poorly understood. Here we document a previously unidentified form of deep-brain photoreception in Xenopus laevis frog tadpoles. The isolated nervous system retains sensitivity to light even when devoid of input from classical eye and pineal photoreceptors. These preparations produce regular bouts of rhythmic swimming activity in ambient light but fall silent in the dark. This sensitivity is tuned to short-wavelength UV light; illumination at 400 nm initiates motor activity over a broad range of intensities, whereas longer wavelengths do not cause a response. The photosensitive tissue is located in a small region of caudal diencephalon—this region is necessary to retain responses to illumination, whereas its focal illumination is sufficient to drive them. We present evidence for photoreception via the light-sensitive proteins opsin (OPN)5 and/or cryptochrome 1, because populations of OPN5-positive and cryptochrome-positive cells reside within the caudal diencephalon. This discovery represents a hitherto undescribed vertebrate pathway that links luminance detection to motor output. The pathway provides a simple mechanism for light avoidance and/or may reinforce classical circadian systems. | |
dc.format.extent | 6 | |
dc.format.extent | 1093723 | |
dc.language.iso | eng | |
dc.relation.ispartof | Proceedings of the National Academy of Sciences of the United States of America | en |
dc.subject | Photoreception | en |
dc.subject | Locomotion | en |
dc.subject | CPG | en |
dc.subject | Opsin 5 | en |
dc.subject | Cytochrome | en |
dc.subject | QH301 Biology | en |
dc.subject | RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry | en |
dc.subject | NDAS | en |
dc.subject | BDC | en |
dc.subject | R2C | en |
dc.subject.lcc | QH301 | en |
dc.subject.lcc | RC0321 | en |
dc.title | Deep-brain photoreception links luminance detection to motor output in Xenopus frog tadpoles | en |
dc.type | Journal article | en |
dc.contributor.institution | University of St Andrews. School of Psychology and Neuroscience | en |
dc.contributor.institution | University of St Andrews. Institute of Behavioural and Neural Sciences | en |
dc.identifier.doi | 10.1073/pnas.1515516113 | |
dc.description.status | Peer reviewed | en |
dc.date.embargoedUntil | 2016-11-10 | |
dc.identifier.url | https://www.pnas.org/content/suppl/2016/05/09/1515516113.DCSupplemental | en |
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