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The synthesis and biological evaluation of d-myo-inositol 1,4,5-trisphosphate receptor ligands
Item metadata
dc.contributor.advisor | Conway, Stuart J. | |
dc.contributor.author | Keddie, Neil S. | |
dc.coverage.spatial | 382 | en_US |
dc.date.accessioned | 2010-07-09T12:23:10Z | |
dc.date.available | 2010-07-09T12:23:10Z | |
dc.date.issued | 2010-06 | |
dc.identifier | uk.bl.ethos.552360 | |
dc.identifier.uri | https://hdl.handle.net/10023/963 | |
dc.description.abstract | The intracellular second messenger InsP₃ is a vital molecule in the regulation of Ca²⁺ signalling. Ca²⁺ mediates a wide range of cellular activities from fertilisation and cell differentiation through to apoptoisis. Using X-ray crystal structure data and molecular modelling, a series of novel InsP₃ analogues were designed as selective InsP₃R-antagonists. Two novel synthetic routes have been developed for the synthesis of these analogues. The first route uses a Ferrier-II rearrangement to provide enantiopure inositol intermediates, whereas, the second route employs a diastereomeric resolution to obtain the enantiopure inositols. The successful synthesis of InsP₃ and a series of 5-position modified analogues are reported herein. | en_US |
dc.language.iso | en | en_US |
dc.publisher | University of St Andrews | |
dc.rights | Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported | |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/ | |
dc.subject | d-myo-inositol | en_US |
dc.subject | Inositol | en_US |
dc.subject | d-myo-inositol 1,4,5-trisphosphate | en_US |
dc.subject | InsP₃ | en_US |
dc.subject | InsP₃ receptor (InsP₃Rs) | en_US |
dc.subject | InsP₃ receptor ligands | en_US |
dc.subject | Synthesis | en_US |
dc.subject.lcc | QP772.I5K4 | |
dc.subject.lcsh | Inositol phosphates--Synthesis | en_US |
dc.subject.lcsh | Inositol phosphates--Derivatives--Synthesis | en_US |
dc.title | The synthesis and biological evaluation of d-myo-inositol 1,4,5-trisphosphate receptor ligands | en_US |
dc.type | Thesis | en_US |
dc.contributor.sponsor | Biotechnology and Biological Sciences Research Council (BBSRC) | en_US |
dc.type.qualificationlevel | Doctoral | en_US |
dc.type.qualificationname | PhD Doctor of Philosophy | en_US |
dc.publisher.institution | The University of St Andrews | en_US |
dc.publisher.department | Centre for Biomolecular Sciences (CBMS) | en_US |
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