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A systematic review of biomarkers for disease progression in Parkinson's disease

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Zajicek_2013_BMCNeurology_DiseaseProgression_CC.pdf (441.0Kb)
Date
12/04/2013
Author
McGhee, David J. M.
Royle, Pamela L.
Thompson, Paul A.
Wright, David E.
Zajicek, John P.
Counsell, Carl E.
Keywords
Biomarkers
Disease Progression
Humans
Parkinson Disease
Clinical trials
Neuroprotective agents
RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Metadata
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Abstract
BACKGROUND: Using surrogate biomarkers for disease progression as endpoints in neuroprotective clinical trials may help differentiate symptomatic effects of potential neuroprotective agents from true disease-modifying effects. A systematic review was undertaken to determine what biomarkers for disease progression in Parkinson's disease (PD) exist. METHODS: MEDLINE and EMBASE (1950-2010) were searched using five search strategies. Abstracts were assessed to identify papers meriting review in full. Studies of participants with idiopathic PD diagnosed by formal criteria or clearly described clinical means were included. We made no restriction on age, disease duration, drug treatment, or study design. We included studies which attempted to draw associations between any tests used to investigate disease progression and any clinical measures of disease progression. The electronic search was validated by hand-searching the two journals from which most included articles came. RESULTS: 183 studies were included: 163 (89%) cross-sectional, 20 (11%) longitudinal. The electronic search strategy had a sensitivity of 71.4% (95% CI 51.1-86.0) and a specificity of 97.1% (95% CI 96.5-97.7). In longitudinal studies median follow-up was 2.0 years (IQR 1.1-3.5). Included studies were generally poor quality--cross-sectional with small numbers of participants, applying excessive inclusion/exclusion criteria, with flawed methodologies and simplistic statistical analyses. CONCLUSION: We found insufficient evidence to recommend the use of any biomarker for disease progression in PD clinical trials, which may simply reflect the poor quality of research in this area. We therefore present a provisional 'roadmap' for conducting future disease progression biomarker studies, and recommend new quality criteria by which future studies may be judged.
Citation
McGhee , D J M , Royle , P L , Thompson , P A , Wright , D E , Zajicek , J P & Counsell , C E 2013 , ' A systematic review of biomarkers for disease progression in Parkinson's disease ' , BMC Neurology , vol. 13 , 35 . https://doi.org/10.1186/1471-2377-13-35
Publication
BMC Neurology
Status
Peer reviewed
DOI
https://doi.org/10.1186/1471-2377-13-35
ISSN
1471-2377
Type
Journal article
Rights
© 2013 McGhee et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Description
This article presents independent research funded by the National Institute for Health Research (NIHR) under its Programme Grants for Applied Research Programme (Grant Reference Number RP-PG-0707-10124).
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  • University of St Andrews Research
URI
http://hdl.handle.net/10023/9514

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