Statistics

 

The statistics division has research interests in 3 main areas: wildlife population assessment, ecological and environmental modelling, and statistical inference.

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  • Authentication and characterisation of a new oesophageal adenocarcinoma cell line : MFD-1 

    Garcia, Edwin; Hayden, Annette; Birts, Charles; Britton, Edward; Cowie, Andrew; Pickard, Karen; Mellone, Massimiliano; Choh, Clarisa; Derouet, Mathieu; Duriez, Patrick; Noble, Fergus; White, Michael J.; Primrose, John N.; Strefford, Jonathan C.; Rose-Zerilli, Matthew; Thomas, Gareth J.; Ang, Yeng; Sharrocks, Andrew D.; Fitzgerald, Rebecca C.; Underwood, Timothy J.; Lynch, Andy G. (2016-09-07) - Journal article
    New biological tools are required to understand the functional significance of genetic events revealed by whole genome sequencing (WGS) studies in oesophageal adenocarcinoma (OAC). The MFD-1 cell line was isolated from a ...

  • Mutational signatures of ionizing radiation in second malignancies 

    Behjati, Sam; Gundem, Gunes; Wedge, David C.; Roberts, Nicola D.; Tarpey, Patrick S.; Cooke, Susanna L.; Van Loo, Peter; Alexandrov, Ludmil B.; Ramakrishna, Manasa; Davies, Helen; Nik-Zainal, Serena; Hardy, Claire; Latimer, Calli; Raine, Keiran M.; Stebbings, Lucy; Menzies, Andy; Jones, David; Shepherd, Rebecca; Butler, Adam P.; Teague, Jon W.; Jorgensen, Mette; Khatri, Bhavisha; Pillay, Nischalan; Shlien, Adam; Futreal, P. Andrew; Badie, Christophe; McDermott, Ultan; Bova, G. Steven; Richardson, Andrea L.; Flanagan, Adrienne M.; Stratton, Michael R.; Campbell, Peter J.; Lynch, Andrew G. (2016-09-12) - Journal article
    Ionizing radiation is a potent carcinogen, inducing cancer through DNA damage. The signatures of mutations arising in human tissues following in vivo exposure to ionizing radiation have not been documented. Here, we searched ...

  • Whole-genome sequencing of nine esophageal adenocarcinoma cell lines 

    Contino, Gianmarco; Eldridge, Matthew D.; Secrier, Maria; Bower, Lawrence; Elliott, Rachael Fels; Weaver, Jamie; Lynch, Andy G.; Edwards, Paul A.W.; Fitzgerald, Rebecca C. (2016-06-10) - Journal article
    Esophageal adenocarcinoma (EAC) is highly mutated and molecularly heterogeneous. The number of cell lines available for study is limited and their genome has been only partially characterized. The availability of an accurate ...

  • Decomposition of mutational context signatures using quadratic programming methods 

    Lynch, Andy G. (2016-06-07) - Journal article
    Methods for inferring signatures of mutational contexts from large cancer sequencing data sets are invaluable for biological research, but impractical for clinical application where we require tools that decompose the ...

  • A tumor DNA complex aberration index is an independent predictor of survival in breast and ovarian cancer 

    Vollan, Hans Kristian Moen; Rueda, Oscar M.; Chin, Suet-Feung; Curtis, Christina; Turashuili, Gulisa; Shah, Sohrab; Lingjaerde, Ole Christian; Yuan, Yinyin; Ng, Charlotte K.; Dunning, Mark J.; Dicks, Ed; Provenzano, Elena; Sammut, Stephen; McKinney, Steven; Ellis, Ian O.; Pinder, Sarah; Purushotham, Arnie; Murphy, Leigh C.; Kristensen, Vessela N.; Brenton, James D.; Pharoah, Paul D. P.; Borresen-Dale, Anne-Lise; Aparicio, Samuel; Caldas, Carlos; Lynch, Andy (2015-01) - Journal article
    Complex focal chromosomal rearrangements in cancer genomes, also called "firestorms", can be scored from DNA copy number data. The complex arm-wise aberration index (CAAI) is a score that captures DNA copy number alterations ...

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