Now showing items 1-5 of 147

  • Timing the landmark events in the evolution of clear cell renal cell cancer : TRACERx renal 

    Mitchell, Thomas J.; Turajlic, Samra; Rowan, Andrew; Nicol, David; Farmery, James H.R.; O’Brien, Tim; Martincorena, Inigo; Tarpey, Patrick; Angelopoulos, Nicos; Yates, Lucy R.; Butler, Adam P.; Raine, Keiran; Stewart, Grant D.; Challacombe, Ben; Fernando, Archana; Lopez, Jose I.; Hazell, Steve; Chandra, Ashish; Chowdhury, Simon; Rudman, Sarah; Soultati, Aspasia; Stamp, Gordon; Fotiadis, Nicos; Pickering, Lisa; Au, Lewis; Spain, Lavinia; Lynch, Joanna; Stares, Mark; Teague, Jon; Maura, Francesco; Wedge, David C.; Horswell, Stuart; Chambers, Tim; Litchfield, Kevin; Xu, Hang; Stewart, Aengus; Elaidi, Reza; Oudard, Stéphane; McGranahan, Nicholas; Csabai, Istvan; Gore, Martin; Futreal, P. Andrew; Larkin, James; Lynch, Andy G.; Szallasi, Zoltan; Swanton, Charles; Campbell, Peter J. (2018-04-12) - Journal article
    Clear cell renal cell carcinoma (ccRCC) is characterized by near-universal loss of the short arm of chromosome 3, deleting several tumor suppressor genes. We analyzed whole genomes from 95 biopsies across 33 patients with ...
  • Statistical issues in first-in-human studies on BIA 10-2474: neglected comparison of protocol against practice 

    Bird, Sheila M.; Bailey, Rosemary A.; Grieve, Andrew P.; Senn, Stephen (2017-03-15) - Journal article
    By setting the regulatory-approved protocol for a suite of first-in-human studies on BIA 10-2474 against the subsequent French investigations, we highlight six key design and statistical issues which reinforce recommendations ...
  • Sesqui-arrays, a generalisation of triple arrays 

    Bailey, Rosemary Anne; Cameron, Peter Jephson; Nilson, Tomas (2018-02-13) - Journal article
    A triple array is a rectangular array containing letters, each letter occurring equally often with no repeats in rows or columns, such that the number of letters common to two rows, two columns, or a row and a column are ...
  • Telomerecat : a ploidy-agnostic method for estimating telomere length from whole genome sequencing data 

    Farmery, James; Smith, Mike; NIHR BioResource - Rare Diseases; Lynch, Andy (2018-01-22) - Journal article
    Telomere length is a risk factor in disease and the dynamics of telomere length are crucial to our understanding of cell replication and vitality. The proliferation of whole genome sequencing represents an unprecedented ...
  • Point process models for spatio-temporal distance sampling data from a large-scale survey of blue whales 

    Yuan, Y.; Bachl, F. E.; Lindgren, F.; Borchers, David Louis; Illian, J. B.; Buckland, S. T.; Rue, H.; Gerrodette, T. (2017-12) - Journal article
    Distance sampling is a widely used method for estimating wildlife population abundance. The fact that conventional distance sampling methods are partly design-based constrains the spatial resolution at which animal density ...