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dc.contributor.authorZwart, Maarten F.
dc.contributor.authorPulver, Stefan R.
dc.contributor.authorTruman, James W.
dc.contributor.authorFushiki, Akira
dc.contributor.authorFetter, Richard D.
dc.contributor.authorCardona, Albert
dc.contributor.authorLandgraf, Matthias
dc.date.accessioned2016-08-04T11:30:07Z
dc.date.available2016-08-04T11:30:07Z
dc.date.issued2016-08-03
dc.identifier.citationZwart , M F , Pulver , S R , Truman , J W , Fushiki , A , Fetter , R D , Cardona , A & Landgraf , M 2016 , ' Selective inhibition mediates the sequential recruitment of motor pools ' , Neuron , vol. 91 , no. 3 , pp. 615-628 . https://doi.org/10.1016/j.neuron.2016.06.031en
dc.identifier.issn0896-6273
dc.identifier.otherPURE: 244761186
dc.identifier.otherPURE UUID: ce5050a8-b902-4ca9-bfc0-d96c2c41d6fa
dc.identifier.otherScopus: 84978881314
dc.identifier.otherORCID: /0000-0002-5073-8631/work/52572483
dc.identifier.otherWOS: 000382396100015
dc.identifier.otherORCID: /0000-0001-5170-7522/work/69463423
dc.identifier.urihttp://hdl.handle.net/10023/9257
dc.descriptionThis work was supported by the Howard Hughes Medical Institute, the HHMI Janelia Visitor Program (M.F.Z. and M.L.), an Isaac Newton Trust/ISSF Wellcome Trust, and a Wellcome Trust grant (092986/Z) to M.L.en
dc.description.abstractLocomotor systems generate diverse motor patterns to produce the movements underlying behavior, requiring that motor neurons be recruited at various phases of the locomotor cycle. Reciprocal inhibition produces alternating motor patterns; however, the mechanisms that generate other phasic relationships between intrasegmental motor pools are unknown. Here, we investigate one such motor pattern in the Drosophila larva, using a multidisciplinary approach including electrophysiology and ssTEM-based circuit reconstruction. We find that two motor pools that are sequentially recruited during locomotion have identical excitable properties. In contrast, they receive input from divergent premotor circuits. We find that this motor pattern is not orchestrated by differential excitatory input but by a GABAergic interneuron acting as a delay line to the later-recruited motor pool. Our findings show how a motor pattern is generated as a function of the modular organization of locomotor networks through segregation of inhibition, a potentially general mechanism for sequential motor patterns.
dc.format.extent14
dc.language.isoeng
dc.relation.ispartofNeuronen
dc.rights© 2016 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).en
dc.subjectRC0321 Neuroscience. Biological psychiatry. Neuropsychiatryen
dc.subjectQH301 Biologyen
dc.subjectNeuroscience(all)en
dc.subjectNDASen
dc.subjectBDCen
dc.subjectR2Cen
dc.subject.lccRC0321en
dc.subject.lccQH301en
dc.titleSelective inhibition mediates the sequential recruitment of motor poolsen
dc.typeJournal articleen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews.School of Psychology and Neuroscienceen
dc.identifier.doihttps://doi.org/10.1016/j.neuron.2016.06.031
dc.description.statusPeer revieweden


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