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Selective inhibition mediates the sequential recruitment of motor pools

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Pulver_2016_Neuron_MotorPools_CC.pdf (5.053Mb)
Date
03/08/2016
Author
Zwart, Maarten F.
Pulver, Stefan R.
Truman, James W.
Fushiki, Akira
Fetter, Richard D.
Cardona, Albert
Landgraf, Matthias
Keywords
RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
QH301 Biology
Neuroscience(all)
NDAS
BDC
R2C
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Abstract
Locomotor systems generate diverse motor patterns to produce the movements underlying behavior, requiring that motor neurons be recruited at various phases of the locomotor cycle. Reciprocal inhibition produces alternating motor patterns; however, the mechanisms that generate other phasic relationships between intrasegmental motor pools are unknown. Here, we investigate one such motor pattern in the Drosophila larva, using a multidisciplinary approach including electrophysiology and ssTEM-based circuit reconstruction. We find that two motor pools that are sequentially recruited during locomotion have identical excitable properties. In contrast, they receive input from divergent premotor circuits. We find that this motor pattern is not orchestrated by differential excitatory input but by a GABAergic interneuron acting as a delay line to the later-recruited motor pool. Our findings show how a motor pattern is generated as a function of the modular organization of locomotor networks through segregation of inhibition, a potentially general mechanism for sequential motor patterns.
Citation
Zwart , M F , Pulver , S R , Truman , J W , Fushiki , A , Fetter , R D , Cardona , A & Landgraf , M 2016 , ' Selective inhibition mediates the sequential recruitment of motor pools ' , Neuron , vol. 91 , no. 3 , pp. 615-628 . https://doi.org/10.1016/j.neuron.2016.06.031
Publication
Neuron
Status
Peer reviewed
DOI
https://doi.org/10.1016/j.neuron.2016.06.031
ISSN
0896-6273
Type
Journal article
Rights
© 2016 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Description
This work was supported by the Howard Hughes Medical Institute, the HHMI Janelia Visitor Program (M.F.Z. and M.L.), an Isaac Newton Trust/ISSF Wellcome Trust, and a Wellcome Trust grant (092986/Z) to M.L.
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  • University of St Andrews Research
URI
http://hdl.handle.net/10023/9257

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