A one-pot synthesis of symmetrical and unsymmetrical dipeptide ureas

We describe a flexible and high yielding synthesis of 1,3-disubstituted ureas, that allows for the construction of both symmetrical and unsymmetrical dipeptide ureas, including easy access to 13C labelled ureas, from amino acids and carbon dioxide at atmospheric pressure.

Citation

Abou Fayad , A , Pubill Ulldemolins , C , Sharma , S V , Day , D & Goss , R J M 2015 , ' A one-pot synthesis of symmetrical and unsymmetrical dipeptide ureas ' , European Journal of Organic Chemistry , vol. 25 , pp. 5603-5609 . https://doi.org/10.1002/ejoc.201500589

Publication

European Journal of Organic Chemistry

Status

Peer reviewed

DOI

https://doi.org/10.1002/ejoc.201500589

ISSN

1434-193X

Type

Journal article

Rights

Copyright © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. This is the peer reviewed version of the following article: A one-pot synthesis of symmetrical and unsymmetrical dipeptide ureas Abou Fayad, A., Pubill Ulldemolins, C., Sharma, S. V., Day, D. & Goss, R. J. M. 2015 In : European Journal of Organic Chemistry. Early View, 8 p, which has been published in final form at http://dx.doi.org/10.1002/ejoc.201500589. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.

Description

We gratefully acknowledge financial support from the BBSRC (Grant no. BB/I022910/1 and the European Commission (Seventh Framework Programme, Collaborative project "BlueGenics", Grant no. 311848).

Collections

University of St Andrews Research

URI

http://hdl.handle.net/10023/9228