A one-pot synthesis of symmetrical and unsymmetrical dipeptide ureas
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We describe a flexible and high yielding synthesis of 1,3-disubstituted ureas, that allows for the construction of both symmetrical and unsymmetrical dipeptide ureas, including easy access to 13C labelled ureas, from amino acids and carbon dioxide at atmospheric pressure.
Abou Fayad , A , Pubill Ulldemolins , C , Sharma , S V , Day , D & Goss , R J M 2015 , ' A one-pot synthesis of symmetrical and unsymmetrical dipeptide ureas ' European Journal of Organic Chemistry , vol 25 , pp. 5603-5609 . DOI: 10.1002/ejoc.201500589
European Journal of Organic Chemistry
Copyright © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. This is the peer reviewed version of the following article: A one-pot synthesis of symmetrical and unsymmetrical dipeptide ureas Abou Fayad, A., Pubill Ulldemolins, C., Sharma, S. V., Day, D. & Goss, R. J. M. 2015 In : European Journal of Organic Chemistry. Early View, 8 p, which has been published in final form at http://dx.doi.org/10.1002/ejoc.201500589. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
We gratefully acknowledge financial support from the BBSRC (Grant no. BB/I022910/1 and the European Commission (Seventh Framework Programme, Collaborative project "BlueGenics", Grant no. 311848).
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