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Could molecular pathology testing in lung cancer be more cost effective?

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Costings_and_audit_paper.pdf (25.03Kb)
Date
10/2016
Author
Walsh, Kathy
Kheng, Yuan
Oniscu, Anca
Harrison, David James
Wallace, William
Keywords
RB Pathology
RM Therapeutics. Pharmacology
NDAS
SDG 3 - Good Health and Well-being
Metadata
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Abstract
Aims: EGFR and ALK analysis is routinely undertaken prior to targeted treatment of non-squamous non-small cell lung carcinoma (NSCLC). Increasingly limited resources require molecular pathology services to be cost effective without detriment to patient care. Methods: Data from an audit of molecular pathology testing in the South East of Scotland Cancer network has been used to explore different testing strategies with the aim of reducing costs; including investigation of TTF1 expression as a negative predictor for EGFR mutations. Results: TTF1 immunohistochemistry had a high negative predictive value for EGFR mutations (99%). Reflex testing all non-squamous NSCLC had the highest costs whereas limiting testing to those who might be considered for treatment would save 7.5%; the serial model could save 32.7%. Conclusions: Testing only patients being considered for EGFR and ALK inhibitors represented small savings; more significant savings would be achievable if testing algorithms utilized known associations between clinical biomarkers.
Citation
Walsh , K , Kheng , Y , Oniscu , A , Harrison , D J & Wallace , W 2016 , ' Could molecular pathology testing in lung cancer be more cost effective? ' , Journal of Clinical Pathology , vol. 69 , no. 10 , pp. 938-941 . https://doi.org/10.1136/jclinpath-2016-203811
Publication
Journal of Clinical Pathology
Status
Peer reviewed
DOI
https://doi.org/10.1136/jclinpath-2016-203811
ISSN
0021-9746
Type
Journal article
Rights
© 2016, the Author(s). This work is made available online in accordance with the publisher’s policies. This is the author created, accepted version manuscript following peer review and may differ slightly from the final published version. The final published version of this work is available at jcp.bmj.com / https://dx.doi.org/10.1136/jclinpath-2016-203863
Collections
  • University of St Andrews Research
URI
http://hdl.handle.net/10023/9205

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