Show simple item record

Files in this item

Thumbnail

Item metadata

dc.contributor.authorSchubert, Marcel
dc.contributor.authorSteude, Anja
dc.contributor.authorLiehm, Philipp
dc.contributor.authorKronenberg, Nils Michael
dc.contributor.authorKarl, Markus
dc.contributor.authorCampbell, Elaine Catherine
dc.contributor.authorPowis, Simon John
dc.contributor.authorGather, Malte Christian
dc.date.accessioned2016-07-16T23:31:12Z
dc.date.available2016-07-16T23:31:12Z
dc.date.issued2015-08-12
dc.identifier205521045
dc.identifier1a9f6a46-1b08-471f-8cb9-cf4a25b47b08
dc.identifier84939229392
dc.identifier000359613700121
dc.identifier.citationSchubert , M , Steude , A , Liehm , P , Kronenberg , N M , Karl , M , Campbell , E C , Powis , S J & Gather , M C 2015 , ' Lasing within live cells containing intracellular optical microresonators for barcode-type cell tagging and tracking ' , Nano Letters , vol. 15 , no. 8 , pp. 5647-5652 . https://doi.org/10.1021/acs.nanolett.5b02491en
dc.identifier.issn1530-6984
dc.identifier.otherORCID: /0000-0002-4857-5562/work/47136476
dc.identifier.otherORCID: /0000-0002-8739-4852/work/36937594
dc.identifier.otherORCID: /0000-0003-4218-2984/work/60195316
dc.identifier.urihttps://hdl.handle.net/10023/9152
dc.descriptionThis work was supported by the European Union Marie Curie Career Integration Grant (PCIG12-GA-2012-334407) and the Scottish Funding Council (SUPA II). M.S. acknowledges funding by the German Science Foundation (DFG) through a Research Fellowship (SCHU 3003/1-1).en
dc.description.abstractWe report on a laser that is fully embedded into a single live cell. By harnessing natural endocytosis of the cell we introduce a fluorescent whispering gallery mode (WGM) micro-resonator into the cell cytoplasm. On pumping with nanojoule light pulses, green laser emission is generated inside the cells. Our approach can be applied to different cell types and cells with micro-resonators remain viable for weeks under standard conditions. The characteristics of the lasing spectrum provide each cell with a barcode-type label which enables uniquely identifying and tracking of individual migrating cells. Self-sustained lasing from cells paves the way to new forms of cell tracking, intracellular sensing and adaptive imaging.
dc.format.extent6
dc.format.extent1110064
dc.language.isoeng
dc.relation.ispartofNano Lettersen
dc.subjectBiological lasersen
dc.subjectIntracellular lasingen
dc.subjectWhispering Gallery Mode resonatoren
dc.subjectOpsonized beadsen
dc.subjectMultiplexingen
dc.subjectCell tracking and taggingen
dc.subjectR Medicineen
dc.subjectQC Physicsen
dc.subjectNDASen
dc.subjectBDCen
dc.subjectR2Cen
dc.subject.lccRen
dc.subject.lccQCen
dc.titleLasing within live cells containing intracellular optical microresonators for barcode-type cell tagging and trackingen
dc.typeJournal articleen
dc.contributor.sponsorEuropean Commissionen
dc.contributor.institutionUniversity of St Andrews. School of Physics and Astronomyen
dc.contributor.institutionUniversity of St Andrews. School of Medicineen
dc.contributor.institutionUniversity of St Andrews. Biomedical Sciences Research Complexen
dc.identifier.doi10.1021/acs.nanolett.5b02491
dc.description.statusPeer revieweden
dc.date.embargoedUntil2016-07-17
dc.identifier.grantnumberPCIG12-GA-2012-334407en


This item appears in the following Collection(s)

Show simple item record