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Lasing within live cells containing intracellular optical microresonators for barcode-type cell tagging and tracking
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dc.contributor.author | Schubert, Marcel | |
dc.contributor.author | Steude, Anja | |
dc.contributor.author | Liehm, Philipp | |
dc.contributor.author | Kronenberg, Nils Michael | |
dc.contributor.author | Karl, Markus | |
dc.contributor.author | Campbell, Elaine Catherine | |
dc.contributor.author | Powis, Simon John | |
dc.contributor.author | Gather, Malte Christian | |
dc.date.accessioned | 2016-07-16T23:31:12Z | |
dc.date.available | 2016-07-16T23:31:12Z | |
dc.date.issued | 2015-08-12 | |
dc.identifier | 205521045 | |
dc.identifier | 1a9f6a46-1b08-471f-8cb9-cf4a25b47b08 | |
dc.identifier | 84939229392 | |
dc.identifier | 000359613700121 | |
dc.identifier.citation | Schubert , M , Steude , A , Liehm , P , Kronenberg , N M , Karl , M , Campbell , E C , Powis , S J & Gather , M C 2015 , ' Lasing within live cells containing intracellular optical microresonators for barcode-type cell tagging and tracking ' , Nano Letters , vol. 15 , no. 8 , pp. 5647-5652 . https://doi.org/10.1021/acs.nanolett.5b02491 | en |
dc.identifier.issn | 1530-6984 | |
dc.identifier.other | ORCID: /0000-0002-4857-5562/work/47136476 | |
dc.identifier.other | ORCID: /0000-0002-8739-4852/work/36937594 | |
dc.identifier.other | ORCID: /0000-0003-4218-2984/work/60195316 | |
dc.identifier.uri | https://hdl.handle.net/10023/9152 | |
dc.description | This work was supported by the European Union Marie Curie Career Integration Grant (PCIG12-GA-2012-334407) and the Scottish Funding Council (SUPA II). M.S. acknowledges funding by the German Science Foundation (DFG) through a Research Fellowship (SCHU 3003/1-1). | en |
dc.description.abstract | We report on a laser that is fully embedded into a single live cell. By harnessing natural endocytosis of the cell we introduce a fluorescent whispering gallery mode (WGM) micro-resonator into the cell cytoplasm. On pumping with nanojoule light pulses, green laser emission is generated inside the cells. Our approach can be applied to different cell types and cells with micro-resonators remain viable for weeks under standard conditions. The characteristics of the lasing spectrum provide each cell with a barcode-type label which enables uniquely identifying and tracking of individual migrating cells. Self-sustained lasing from cells paves the way to new forms of cell tracking, intracellular sensing and adaptive imaging. | |
dc.format.extent | 6 | |
dc.format.extent | 1110064 | |
dc.language.iso | eng | |
dc.relation.ispartof | Nano Letters | en |
dc.subject | Biological lasers | en |
dc.subject | Intracellular lasing | en |
dc.subject | Whispering Gallery Mode resonator | en |
dc.subject | Opsonized beads | en |
dc.subject | Multiplexing | en |
dc.subject | Cell tracking and tagging | en |
dc.subject | R Medicine | en |
dc.subject | QC Physics | en |
dc.subject | NDAS | en |
dc.subject | BDC | en |
dc.subject | R2C | en |
dc.subject.lcc | R | en |
dc.subject.lcc | QC | en |
dc.title | Lasing within live cells containing intracellular optical microresonators for barcode-type cell tagging and tracking | en |
dc.type | Journal article | en |
dc.contributor.sponsor | European Commission | en |
dc.contributor.institution | University of St Andrews. School of Physics and Astronomy | en |
dc.contributor.institution | University of St Andrews. School of Medicine | en |
dc.contributor.institution | University of St Andrews. Biomedical Sciences Research Complex | en |
dc.identifier.doi | 10.1021/acs.nanolett.5b02491 | |
dc.description.status | Peer reviewed | en |
dc.date.embargoedUntil | 2016-07-17 | |
dc.identifier.grantnumber | PCIG12-GA-2012-334407 | en |
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