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dc.contributor.authorSchubert, Marcel
dc.contributor.authorSteude, Anja
dc.contributor.authorLiehm, Philipp
dc.contributor.authorKronenberg, Nils Michael
dc.contributor.authorKarl, Markus
dc.contributor.authorCampbell, Elaine Catherine
dc.contributor.authorPowis, Simon John
dc.contributor.authorGather, Malte Christian
dc.date.accessioned2016-07-16T23:31:12Z
dc.date.available2016-07-16T23:31:12Z
dc.date.issued2015-08-12
dc.identifier.citationSchubert , M , Steude , A , Liehm , P , Kronenberg , N M , Karl , M , Campbell , E C , Powis , S J & Gather , M C 2015 , ' Lasing within live cells containing intracellular optical microresonators for barcode-type cell tagging and tracking ' , Nano Letters , vol. 15 , no. 8 , pp. 5647-5652 . https://doi.org/10.1021/acs.nanolett.5b02491en
dc.identifier.issn1530-6984
dc.identifier.otherPURE: 205521045
dc.identifier.otherPURE UUID: 1a9f6a46-1b08-471f-8cb9-cf4a25b47b08
dc.identifier.otherScopus: 84939229392
dc.identifier.otherORCID: /0000-0002-4857-5562/work/47136476
dc.identifier.otherORCID: /0000-0002-8739-4852/work/36937594
dc.identifier.otherORCID: /0000-0003-4218-2984/work/60195316
dc.identifier.otherWOS: 000359613700121
dc.identifier.urihttp://hdl.handle.net/10023/9152
dc.descriptionThis work was supported by the European Union Marie Curie Career Integration Grant (PCIG12-GA-2012-334407) and the Scottish Funding Council (SUPA II). M.S. acknowledges funding by the German Science Foundation (DFG) through a Research Fellowship (SCHU 3003/1-1).en
dc.description.abstractWe report on a laser that is fully embedded into a single live cell. By harnessing natural endocytosis of the cell we introduce a fluorescent whispering gallery mode (WGM) micro-resonator into the cell cytoplasm. On pumping with nanojoule light pulses, green laser emission is generated inside the cells. Our approach can be applied to different cell types and cells with micro-resonators remain viable for weeks under standard conditions. The characteristics of the lasing spectrum provide each cell with a barcode-type label which enables uniquely identifying and tracking of individual migrating cells. Self-sustained lasing from cells paves the way to new forms of cell tracking, intracellular sensing and adaptive imaging.
dc.format.extent6
dc.language.isoeng
dc.relation.ispartofNano Lettersen
dc.rightsCopyright 2015 American Chemical Society. This document is the Accepted Manuscript version of a Published Work that appeared in final form in Nano Letters, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://pubs.acs.org/doi/abs/10.1021/acs.nanolett.5b02491en
dc.subjectBiological lasersen
dc.subjectIntracellular lasingen
dc.subjectWhispering Gallery Mode resonatoren
dc.subjectOpsonized beadsen
dc.subjectMultiplexingen
dc.subjectCell tracking and taggingen
dc.subjectR Medicineen
dc.subjectQC Physicsen
dc.subjectNDASen
dc.subjectBDCen
dc.subjectR2Cen
dc.subject.lccRen
dc.subject.lccQCen
dc.titleLasing within live cells containing intracellular optical microresonators for barcode-type cell tagging and trackingen
dc.typeJournal articleen
dc.description.versionPostprinten
dc.contributor.institutionUniversity of St Andrews.School of Physics and Astronomyen
dc.contributor.institutionUniversity of St Andrews.School of Medicineen
dc.contributor.institutionUniversity of St Andrews.Biomedical Sciences Research Complexen
dc.identifier.doihttps://doi.org/10.1021/acs.nanolett.5b02491
dc.description.statusPeer revieweden
dc.date.embargoedUntil2016-07-17


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