New insights into photodynamic therapy treatment through the use of 3D Monte Carlo radiation transfer modelling
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Photodynamic therapy (PDT) has been theoretically investigated using a Monte Carlo radiation transfer (MCRT) model. By including complex three dimensional (3D) tumour models a more appropriate representation of the treatment was achieved. The 3D clustered tumour model was compared to a smooth model, resulting in a significantly deeper penetration associated with the clustered model. The results from the work presented here indicates that light might penetrate deeper than suggested by 2D or simple layered models.
Campbell , C L , Wood , K , Brown , C T A & Moseley , H 2016 , New insights into photodynamic therapy treatment through the use of 3D Monte Carlo radiation transfer modelling . in B Choi , N Kollias , H Zeng , H Wook Kang , B J F Wong , J F Ilgner , G J Tearney , K W Gregory , L Marcu , M C Skala , P J Campagnola , A Mandelis & M D Morris (eds) , Photonic Therapeutics and Diagnostics XII . , 96890Q , Proceedings of SPIE , vol. 9689 , SPIE , Photonic Therapeutics and Diagnostics XII , San Francisco , United States , 13-14 February . DOI: 10.1117/12.2212240conference
Photonic Therapeutics and Diagnostics XII
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We acknowledge the support of the UK Engineering and Physics Sciences Research Council (EPSRC) for funding through a studentship for C L Campbell (EP/K503162/1), the Alfred Stewart Trust as well as the BMLA Education Award.