New insights into photodynamic therapy treatment through the use of 3D Monte Carlo radiation transfer modelling
Abstract
Photodynamic therapy (PDT) has been theoretically investigated using a Monte Carlo radiation transfer (MCRT) model. By including complex three dimensional (3D) tumour models a more appropriate representation of the treatment was achieved. The 3D clustered tumour model was compared to a smooth model, resulting in a significantly deeper penetration associated with the clustered model. The results from the work presented here indicates that light might penetrate deeper than suggested by 2D or simple layered models.
Citation
Campbell , C L , Wood , K , Brown , C T A & Moseley , H 2016 , New insights into photodynamic therapy treatment through the use of 3D Monte Carlo radiation transfer modelling . in B Choi , N Kollias , H Zeng , H Wook Kang , B J F Wong , J F Ilgner , G J Tearney , K W Gregory , L Marcu , M C Skala , P J Campagnola , A Mandelis & M D Morris (eds) , Photonic Therapeutics and Diagnostics XII . , 96890Q , Proceedings of SPIE , vol. 9689 , SPIE , Photonic Therapeutics and Diagnostics XII , San Francisco , United States , 13/02/16 . DOI: 10.1117/12.2212240 conference
Publication
Photonic Therapeutics and Diagnostics XII
ISSN
0277-786XRights
© 2016, SPIE. This work is made available online in accordance with the publisher’s policies. This is the final published version of the work, which was originally published at proceedings.spiedigitallibrary.org / https://dx.doi.org/10.1117/12.2212240
Description
We acknowledge the support of the UK Engineering and Physics Sciences Research Council (EPSRC) for funding through a studentship for C L Campbell (EP/K503162/1), the Alfred Stewart Trust as well as the BMLA Education Award.Items in the St Andrews Research Repository are protected by copyright, with all rights reserved, unless otherwise indicated.