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dc.contributor.authorHeutz, Frank
dc.contributor.authorKamer, Paul C J
dc.identifier.citationHeutz , F & Kamer , P C J 2016 , ' Modular solid-phase synthesis, catalytic application and efficient recycling of supported phosphine-phosphite ligand libraries ' , Dalton Transactions , vol. 45 , no. 5 , pp. 2116-2123 .
dc.identifier.otherPURE: 242547825
dc.identifier.otherPURE UUID: 0e288f6b-ad2d-4e33-a0dc-61f8b1e0e9e8
dc.identifier.otherScopus: 84956620602
dc.identifier.otherWOS: 000369413700037
dc.descriptionThe authors thank the European Union (Marie Curie ITN SusPhos, grant agreement no. 317404) for financial support.en
dc.description.abstractIn spite of decades of research in the field of homogeneous asymmetric catalysis the discovery of new high performance catalysts still relies heavily on trial-and-error. There is still a lack of efficient combinatorial methods which enable the synthesis and screening of vast ligand libraries, especially for bidentate phosphorus ligands. Here we present a highly modular solid-phase synthetic approach which provides facile access to libraries of phosphine-phosphite ligands in quantitative yield requiring only minimal work-up. The obtained library of supported phosphine-phosphites was successfully applied in rhodium catalyzed asymmetric hydrogenation obtaining high enantioselectivities up to 98%. Also, these polymer supported ligands could be successfully recycled under batch conditions exhibiting only a small decline of activity and no loss of selectivity.
dc.relation.ispartofDalton Transactionsen
dc.rightsCopyright 2015 the Authors. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence (
dc.subjectQD Chemistryen
dc.titleModular solid-phase synthesis, catalytic application and efficient recycling of supported phosphine-phosphite ligand librariesen
dc.typeJournal articleen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews.School of Chemistryen
dc.contributor.institutionUniversity of St Andrews.EaSTCHEMen
dc.description.statusPeer revieweden

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