Modular solid-phase synthesis, catalytic application and efficient recycling of supported phosphine-phosphite ligand libraries
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In spite of decades of research in the field of homogeneous asymmetric catalysis the discovery of new high performance catalysts still relies heavily on trial-and-error. There is still a lack of efficient combinatorial methods which enable the synthesis and screening of vast ligand libraries, especially for bidentate phosphorus ligands. Here we present a highly modular solid-phase synthetic approach which provides facile access to libraries of phosphine-phosphite ligands in quantitative yield requiring only minimal work-up. The obtained library of supported phosphine-phosphites was successfully applied in rhodium catalyzed asymmetric hydrogenation obtaining high enantioselectivities up to 98%. Also, these polymer supported ligands could be successfully recycled under batch conditions exhibiting only a small decline of activity and no loss of selectivity.
Heutz , F & Kamer , P C J 2016 , ' Modular solid-phase synthesis, catalytic application and efficient recycling of supported phosphine-phosphite ligand libraries ' , Dalton Transactions , vol. 45 , no. 5 , pp. 2116-2123 . https://doi.org/10.1039/C5DT03226A
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