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Management of multidrug-resistant TB : novel treatments and their expansion to low resource settings

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Sloan_2016_Multidrug_resistantTB_TransRoySocTropMed_Hyg_CC.pdf (579.2Kb)
Date
03/2016
Author
Sloan, Derek James
Lewis, Joseph M.
Keywords
Bedaquiline
Delamanid
Extensively drug-resistant
Linezolid
Multidrug-resistant
Tuberculosis
RA0421 Public health. Hygiene. Preventive Medicine
QR180 Immunology
Parasitology
Infectious Diseases
Public Health, Environmental and Occupational Health
SDG 3 - Good Health and Well-being
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Abstract
Despite overall progress in global TB control, the rising burden ofmultidrug-resistant TB (MDR-TB) threatens to undermine efforts to end theworldwide epidemic. Of the 27 countries classified as high burden for MDR-TB, 17 are in 'low' or 'low-middle' income countries. Shorter, all oral and less toxic multidrug combinations are required to improve treatment outcomes in these settings. Suitability for safe co-administration with HIV drugs is also desirable. A range of strategies and several new drugs (including bedaquiline, delamanid and linezolid) are currently undergoing advanced clinical evaluations to define their roles in achieving these aims. However, several clinical questions and logistical challenges need to be overcome before these new MDR-TB treatments fulfil their potential.
Citation
Sloan , D J & Lewis , J M 2016 , ' Management of multidrug-resistant TB : novel treatments and their expansion to low resource settings ' , Transactions of the Royal Society of Tropical Medicine and Hygiene , vol. 110 , no. 3 , trv107 , pp. 163-172 . https://doi.org/10.1093/trstmh/trv107
Publication
Transactions of the Royal Society of Tropical Medicine and Hygiene
Status
Peer reviewed
DOI
https://doi.org/10.1093/trstmh/trv107
ISSN
0035-9203
Type
Journal item
Rights
© The Author 2016. Published by Oxford University Press on behalf of Royal Society of Tropical Medicine and Hygiene. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
Description
This article received no specific funding. JL is supported by the Wellcome Trust as a clinical PhD fellow [grant number 109105/Z/15/Z].
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  • University of St Andrews Research
URI
http://hdl.handle.net/10023/8652

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