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dc.contributor.authorSloan, Derek James
dc.contributor.authorMwandumba, H. C.
dc.contributor.authorKamdolozi, M.
dc.contributor.authorShani, D.
dc.contributor.authorChisale, B.
dc.contributor.authorDutton, J.
dc.contributor.authorKhoo, S. H.
dc.contributor.authorAllain, T. J.
dc.contributor.authorDavies, G. R.
dc.identifier.citationSloan , D J , Mwandumba , H C , Kamdolozi , M , Shani , D , Chisale , B , Dutton , J , Khoo , S H , Allain , T J & Davies , G R 2015 , ' Vitamin D deficiency in Malawian adults with pulmonary tuberculosis : risk factors and treatment outcomes ' , International Journal of Tuberculosis and Lung Disease , vol. 19 , no. 8 , pp. 904-911 .
dc.identifier.otherPURE: 241920764
dc.identifier.otherPURE UUID: 72665a77-18c0-4e24-ae2c-16eb36d093b3
dc.identifier.otherScopus: 84938221168
dc.identifier.otherORCID: /0000-0002-7888-5449/work/60631019
dc.descriptionThe study was supported by a Wellcome Trust (London, UK) Clinical PhD Fellowship awarded to DS (086757/Z/08/A) and the Malawi Liverpool Wellcome Trust (MLW) Core grant from the Wellcome Trust.en
dc.description.abstractSETTING: Vitamin D deficiency is common in African adults with tuberculosis (TB), and may be exacerbated by the metabolic effects of anti-tuberculosis drugs and antiretroviral therapy (ART). It is unclear whether vitamin D deficiency influences response to antituberculosis treatment. OBJECTIVES : To describe risk factors for baseline vitamin D deficiency in Malawian adults with pulmonary TB, assess the relationship between serum 25-hydroxy vitamin D (25[OH]D) concentration and treatment response, and evaluate whether the administration of anti-tuberculosis drugs and ART is deleterious to vitamin D status during treatment. DESIGN: A prospective longitudinal cohort study. RESULTS : The median baseline 25(OH)D concentration of the 169 patients (58% human immunodeficiency virus [HIV] infected) recruited was 57 nmol/l; 47 (28%) had vitamin D deficiency (<50 nmol/l). Baseline 25(OH)D concentrations were lower during the cold season (P < 0.001), with food insecurity (P = 0.034) or in patients who consumed alcohol (P = 0.019). No relationship between vitamin D status and anti-tuberculosis treatment response was found. 25(OH)D concentrations increased during anti-tuberculosis treatment, irrespective of HIV status or use of ART. CONCLUSIONS : Vitamin D deficiency is common among TB patients in Malawi, but this does not influence treatment response. Adverse metabolic effects of drug treatment may be compensated by the positive impact of clinical recovery preventing exacerbation of vitamin D deficiency during anti-tuberculosis treatment.
dc.relation.ispartofInternational Journal of Tuberculosis and Lung Diseaseen
dc.rights© 2015 Sloan et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en
dc.subjectAntiretroviral therapyen
dc.subjectTreatment failureen
dc.subjectRA0421 Public health. Hygiene. Preventive Medicineen
dc.subjectPulmonary and Respiratory Medicineen
dc.subjectInfectious Diseasesen
dc.subjectSDG 2 - Zero Hungeren
dc.subjectSDG 3 - Good Health and Well-beingen
dc.titleVitamin D deficiency in Malawian adults with pulmonary tuberculosis : risk factors and treatment outcomesen
dc.typeJournal articleen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews. School of Medicineen
dc.description.statusPeer revieweden

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